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Page 1
Surface patches induce nonspecific binding and phase separation of antibodies.
Ausserwöger H, Krainer G, Welsh TJ, Thorsteinson N, de Csilléry E, Sneideris T, Schneider MM, Egebjerg T, Invernizzi G, Herling TW, Lorenzen N, Knowles TPJ. Ausserwöger H, et al. Among authors: lorenzen n. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2210332120. doi: 10.1073/pnas.2210332120. Epub 2023 Apr 3. Proc Natl Acad Sci U S A. 2023. PMID: 37011217 Free PMC article.
Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.
Kurnik M, Sahin C, Andersen CB, Lorenzen N, Giehm L, Mohammad-Beigi H, Jessen CM, Pedersen JS, Christiansen G, Petersen SV, Staal R, Krishnamurthy G, Pitts K, Reinhart PH, Mulder FAA, Mente S, Hirst WD, Otzen DE. Kurnik M, et al. Among authors: lorenzen n. Cell Chem Biol. 2018 Nov 15;25(11):1389-1402.e9. doi: 10.1016/j.chembiol.2018.08.005. Epub 2018 Sep 6. Cell Chem Biol. 2018. PMID: 30197194 Free article.
High stability and cooperative unfolding of α-synuclein oligomers.
Paslawski W, Andreasen M, Nielsen SB, Lorenzen N, Thomsen K, Kaspersen JD, Pedersen JS, Otzen DE. Paslawski W, et al. Among authors: lorenzen n. Biochemistry. 2014 Oct 7;53(39):6252-63. doi: 10.1021/bi5007833. Epub 2014 Sep 24. Biochemistry. 2014. PMID: 25216651
A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Østergaard H, Lund J, Greisen PJ, Kjellev S, Henriksen A, Lorenzen N, Johansson E, Røder G, Rasch MG, Johnsen LB, Egebjerg T, Lund S, Rahbek-Nielsen H, Gandhi PS, Lamberth K, Loftager M, Andersen LM, Bonde AC, Stavenuiter F, Madsen DE, Li X, Holm TL, Ley CD, Thygesen P, Zhu H, Zhou R, Thorn K, Yang Z, Hermit MB, Bjelke JR, Hansen BG, Hilden I. Østergaard H, et al. Among authors: lorenzen n. Blood. 2021 Oct 7;138(14):1258-1268. doi: 10.1182/blood.2020010331. Blood. 2021. PMID: 34077951 Free PMC article.
Design of Biopharmaceutical Formulations Accelerated by Machine Learning.
Narayanan H, Dingfelder F, Condado Morales I, Patel B, Heding KE, Bjelke JR, Egebjerg T, Butté A, Sokolov M, Lorenzen N, Arosio P. Narayanan H, et al. Among authors: lorenzen n. Mol Pharm. 2021 Oct 4;18(10):3843-3853. doi: 10.1021/acs.molpharmaceut.1c00469. Epub 2021 Sep 14. Mol Pharm. 2021. PMID: 34519511 Free article.
125 results