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Page 1
Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation.
Papadopoulos N, Nédélec A, Derenne A, Şulea TA, Pecquet C, Chachoua I, Vertenoeil G, Tilmant T, Petrescu AJ, Mazzucchelli G, Iorga BI, Vertommen D, Constantinescu SN. Papadopoulos N, et al. Among authors: constantinescu sn. Nat Commun. 2023 Apr 5;14(1):1881. doi: 10.1038/s41467-023-37277-3. Nat Commun. 2023. PMID: 37019903 Free PMC article.
Mining for JAK-STAT mutations in cancer.
Constantinescu SN, Girardot M, Pecquet C. Constantinescu SN, et al. Trends Biochem Sci. 2008 Mar;33(3):122-31. doi: 10.1016/j.tibs.2007.12.002. Trends Biochem Sci. 2008. PMID: 18291658 Review.
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.
Pecquet C, Staerk J, Chaligné R, Goss V, Lee KA, Zhang X, Rush J, Van Hees J, Poirel HA, Scheiff JM, Vainchenker W, Giraudier S, Polakiewicz RD, Constantinescu SN. Pecquet C, et al. Among authors: constantinescu sn. Blood. 2010 Feb 4;115(5):1037-48. doi: 10.1182/blood-2008-10-183558. Epub 2009 Dec 8. Blood. 2010. PMID: 19996410 Free article.
Orientation-specific signalling by thrombopoietin receptor dimers.
Staerk J, Defour JP, Pecquet C, Leroy E, Antoine-Poirel H, Brett I, Itaya M, Smith SO, Vainchenker W, Constantinescu SN. Staerk J, et al. Among authors: constantinescu sn. EMBO J. 2011 Sep 2;30(21):4398-413. doi: 10.1038/emboj.2011.315. EMBO J. 2011. PMID: 21892137 Free PMC article.
Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.
Pecquet C, Diaconu CC, Staerk J, Girardot M, Marty C, Royer Y, Defour JP, Dusa A, Besancenot R, Giraudier S, Villeval JL, Knoops L, Courtoy PJ, Vainchenker W, Constantinescu SN. Pecquet C, et al. Among authors: constantinescu sn. Blood. 2012 May 17;119(20):4625-35. doi: 10.1182/blood-2011-08-372524. Epub 2012 Feb 29. Blood. 2012. PMID: 22378845 Free article.
209 results