Toh SH - Search Results

1

Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma.

Zhou J, Toh SH, Tan TK, Balan K, Lim JQ, Tan TZ, Xiong S, Jia Y, Ng SB, Peng Y, Jeyasekharan AD, Fan S, Lim ST, Ong CJ, Ong CK, Sanda T, Chng WJ. Zhou J, et al. Among authors: toh sh. Mol Cancer. 2023 Apr 10;22(1):69. doi: 10.1186/s12943-023-01767-1. Mol Cancer. 2023. PMID: 37032358 Free PMC article.

2

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia.

Zhou J, Bi C, Ching YQ, Chooi JY, Lu X, Quah JY, Toh SH, Chan ZL, Tan TZ, Chong PS, Chng WJ. Zhou J, et al. Among authors: toh sh. J Hematol Oncol. 2017 Jul 11;10(1):138. doi: 10.1186/s13045-017-0507-y. J Hematol Oncol. 2017. PMID: 28693523 Free PMC article.

3

A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase.

Zhou J, Toh SH, Chan ZL, Quah JY, Chooi JY, Tan TZ, Chong PSY, Zeng Q, Chng WJ. Zhou J, et al. Among authors: toh sh. J Hematol Oncol. 2018 Mar 7;11(1):36. doi: 10.1186/s13045-018-0581-9. J Hematol Oncol. 2018. PMID: 29514683 Free PMC article.

4

NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B.

Zhou J, Chooi JY, Ching YQ, Quah JY, Toh SH, Ng Y, Tan TZ, Chng WJ. Zhou J, et al. Among authors: toh sh. World J Stem Cells. 2018 Apr 26;10(4):34-42. doi: 10.4252/wjsc.v10.i4.34. World J Stem Cells. 2018. PMID: 29707103 Free PMC article.

5

Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia.

Chong PSY, Zhou J, Chooi JY, Chan ZL, Toh SHM, Tan TZ, Wee S, Gunaratne J, Zeng Q, Chng WJ. Chong PSY, et al. Oncogene. 2019 Feb;38(9):1508-1519. doi: 10.1038/s41388-018-0526-3. Epub 2018 Oct 10. Oncogene. 2019. PMID: 30305722

6

SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma.

Chong PSY, Chooi JY, Lim JSL, Toh SHM, Tan TZ, Chng WJ. Chong PSY, et al. Cancer Res. 2021 May 1;81(9):2332-2344. doi: 10.1158/0008-5472.CAN-20-2946. Epub 2021 Feb 18. Cancer Res. 2021. PMID: 33602783

7

Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma.

Mustafa N, Nee AHF, Chooi JY, Toh SHM, Chung TH, Selvarajan V, Fan S, Ng SB, Poon M, Chan E, Lee J, Chee YL, Jeyasekharan AD, Zhou L, Yang J, Chng WJ. Mustafa N, et al. J Immunother Cancer. 2021 Jul;9(7):e002123. doi: 10.1136/jitc-2020-002123. J Immunother Cancer. 2021. PMID: 34215687 Free PMC article.

8

Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma.

Chong PSY, Chooi JY, Lim JSL, Leow ACY, Toh SHM, Azaman I, Koh MY, Teoh PJ, Tan TZ, Chung TH, Chng WJ. Chong PSY, et al. Among authors: toh shm. Cancer Res. 2023 Oct 13;83(20):3414-3427. doi: 10.1158/0008-5472.CAN-22-3481. Cancer Res. 2023. PMID: 37463241

9

Epigenetic dysregulation of eukaryotic initiation factor 3 subunit E (eIF3E) by lysine methyltransferase REIIBP confers a pro-inflammatory phenotype in t(4;14) myeloma.

Chong PSY, Chooi JY, Lim SLJ, Chung TH, Brunmeir R, Leow ACY, Toh SHM, Balan K, Azaman MIB, Wu Z, Subramaniam N, Vardy LA, Chng WJ. Chong PSY, et al. Among authors: toh shm. Haematologica. 2024 Jun 1;109(6):1893-1908. doi: 10.3324/haematol.2023.283467. Haematologica. 2024. PMID: 38124661 Free PMC article.

10

Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma.

Xiong S, Zhou J, Tan TK, Chung TH, Tan TZ, Toh SH, Tang NXN, Jia Y, See YX, Fullwood MJ, Sanda T, Chng WJ. Xiong S, et al. Among authors: toh sh. Nat Commun. 2024 Aug 9;15(1):6810. doi: 10.1038/s41467-024-50910-z. Nat Commun. 2024. PMID: 39122682 Free PMC article.

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