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Page 1
IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance.
Johnson Z, Tarantelli C, Civanelli E, Cascione L, Spriano F, Fraser A, Shah P, Nomanbhoy T, Napoli S, Rinaldi A, Niewola-Staszkowska K, Lahn M, Perrin D, Wenes M, Migliorini D, Bertoni F, van der Veen L, Di Conza G. Johnson Z, et al. Among authors: wenes m. Cancer Res Commun. 2023 Apr 14;3(4):576-591. doi: 10.1158/2767-9764.CRC-22-0477. eCollection 2023 Apr. Cancer Res Commun. 2023. PMID: 37066023 Free PMC article.
Reductive carboxylation epigenetically instructs T cell differentiation.
Jaccard A, Wyss T, Maldonado-Pérez N, Rath JA, Bevilacqua A, Peng JJ, Lepez A, Von Gunten C, Franco F, Kao KC, Camviel N, Martín F, Ghesquière B, Migliorini D, Arber C, Romero P, Ho PC, Wenes M. Jaccard A, et al. Among authors: wenes m. Nature. 2023 Sep;621(7980):849-856. doi: 10.1038/s41586-023-06546-y. Epub 2023 Sep 20. Nature. 2023. PMID: 37730993
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy.
Ghasemi A, Martinez-Usatorre A, Li L, Hicham M, Guichard A, Marcone R, Fournier N, Torchia B, Martinez Bedoya D, Davanture S, Fernández-Vaquero M, Fan C, Janzen J, Mohammadzadeh Y, Genolet R, Mansouri N, Wenes M, Migliorini D, Heikenwalder M, De Palma M. Ghasemi A, et al. Among authors: wenes m. Nat Cancer. 2024 Feb;5(2):240-261. doi: 10.1038/s43018-023-00668-y. Epub 2023 Nov 23. Nat Cancer. 2024. PMID: 37996514 Free PMC article.
Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma.
Maldonado-Pérez N, Tristán-Manzano M, Justicia-Lirio P, Martínez-Planes E, Muñoz P, Pavlovic K, Cortijo-Gutiérrez M, Blanco-Benítez C, Castella M, Juan M, Wenes M, Romero P, Molina-Estévez FJ, Marañón C, Herrera C, Benabdellah K, Martin F. Maldonado-Pérez N, et al. Among authors: wenes m. Front Immunol. 2022 Oct 6;13:1011858. doi: 10.3389/fimmu.2022.1011858. eCollection 2022. Front Immunol. 2022. PMID: 36275777 Free PMC article.
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.
Wenes M, Jaccard A, Wyss T, Maldonado-Pérez N, Teoh ST, Lepez A, Renaud F, Franco F, Waridel P, Yacoub Maroun C, Tschumi B, Dumauthioz N, Zhang L, Donda A, Martín F, Migliorini D, Lunt SY, Ho PC, Romero P. Wenes M, et al. Cell Metab. 2022 May 3;34(5):731-746.e9. doi: 10.1016/j.cmet.2022.03.013. Epub 2022 Apr 21. Cell Metab. 2022. PMID: 35452600 Free PMC article.
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity.
Guo Y, Xie YQ, Gao M, Zhao Y, Franco F, Wenes M, Siddiqui I, Bevilacqua A, Wang H, Yang H, Feng B, Xie X, Sabatel CM, Tschumi B, Chaiboonchoe A, Wang Y, Li W, Xiao W, Held W, Romero P, Ho PC, Tang L. Guo Y, et al. Among authors: wenes m. Nat Immunol. 2021 Jun;22(6):746-756. doi: 10.1038/s41590-021-00940-2. Epub 2021 May 24. Nat Immunol. 2021. PMID: 34031618 Free PMC article.
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