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Page 1
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells.
Eicher AK, Kechele DO, Sundaram N, Berns HM, Poling HM, Haines LE, Sanchez JG, Kishimoto K, Krishnamurthy M, Han L, Zorn AM, Helmrath MA, Wells JM. Eicher AK, et al. Among authors: kechele do. Cell Stem Cell. 2022 Jan 6;29(1):36-51.e6. doi: 10.1016/j.stem.2021.10.010. Epub 2021 Dec 1. Cell Stem Cell. 2022. PMID: 34856121 Free PMC article.
Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients With PDX1 Mutations.
Krishnamurthy M, Kechele DO, Broda T, Zhang X, Enriquez JR, McCauley HA, Sanchez JG, McCracken K, Palermo J, Bernieh A, Collins MH, Thomas IH, Neef HC, Heider A, Dauber A, Wells JM. Krishnamurthy M, et al. Among authors: kechele do. Gastroenterology. 2022 Oct;163(4):1053-1063.e7. doi: 10.1053/j.gastro.2022.06.083. Epub 2022 Jul 6. Gastroenterology. 2022. PMID: 35803312 Free PMC article.
Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation.
Pitstick AL, Poling HM, Sundaram N, Lewis PL, Kechele DO, Sanchez JG, Scott MA, Broda TR, Helmrath MA, Wells JM, Mayhew CN. Pitstick AL, et al. Among authors: kechele do. Stem Cell Reports. 2022 Aug 9;17(8):1889-1902. doi: 10.1016/j.stemcr.2022.06.011. Epub 2022 Jul 28. Stem Cell Reports. 2022. PMID: 35905739 Free PMC article.
Enteroendocrine Cells Protect the Stem Cell Niche by Regulating Crypt Metabolism in Response to Nutrients.
McCauley HA, Riedman AM, Enriquez JR, Zhang X, Watanabe-Chailland M, Sanchez JG, Kechele DO, Paul EF, Riley K, Burger C, Lang RA, Wells JM. McCauley HA, et al. Among authors: kechele do. Cell Mol Gastroenterol Hepatol. 2023;15(6):1293-1310. doi: 10.1016/j.jcmgh.2022.12.016. Epub 2023 Jan 4. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36608902 Free PMC article.
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon.
Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu YC, Takebe T, Helmrath MA, Wells JM. Múnera JO, et al. Among authors: kechele do. Cell Stem Cell. 2023 Nov 2;30(11):1434-1451.e9. doi: 10.1016/j.stem.2023.10.002. Cell Stem Cell. 2023. PMID: 37922878 Free PMC article.
RFX6 regulates human intestinal patterning and function upstream of PDX1.
Sanchez JG, Rankin S, Paul E, McCauley HA, Kechele DO, Enriquez JR, Jones NH, Greeley SAW, Letourneau-Frieberg L, Zorn AM, Krishnamurthy M, Wells JM. Sanchez JG, et al. Among authors: kechele do. Development. 2024 May 1;151(9):dev202529. doi: 10.1242/dev.202529. Epub 2024 May 9. Development. 2024. PMID: 38587174
RFX6 regulates human intestinal patterning and function upstream of PDX1.
Sanchez JG, Rankin S, Paul E, McCauley HA, Kechele DO, Enriquez JR, Jones NH, Greeley SAW, Letourneau-Freiberg L, Zorn AM, Krishnamurthy M, Wells JM. Sanchez JG, et al. Among authors: kechele do. Development. 2024 Sep 15;151(18):dev204379. doi: 10.1242/dev.204379. Epub 2024 Sep 20. Development. 2024. PMID: 39302049 Free PMC article. No abstract available.
20 results