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260 results

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Page 1
Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs.
Xie X, Patnana PK, Frank D, Schütte J, Al-Matary Y, Künstner A, Busch H, Ahmed H, Liu L, Engel DR, Dührsen U, Rosenbauer F, Von Bubnoff N, Lenz G, Khandanpour C. Xie X, et al. Among authors: schutte j. Front Cell Dev Biol. 2023 Apr 5;11:866847. doi: 10.3389/fcell.2023.866847. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37091981 Free PMC article.
Enforced GFI1 expression impedes human and murine leukemic cell growth.
Hönes JM, Thivakaran A, Botezatu L, Patnana P, Castro SVDC, Al-Matary YS, Schütte J, Fischer KBI, Vassen L, Görgens A, Dührsen U, Giebel B, Khandanpour C. Hönes JM, et al. Among authors: schutte j. Sci Rep. 2017 Nov 16;7(1):15720. doi: 10.1038/s41598-017-15866-9. Sci Rep. 2017. PMID: 29147018 Free PMC article.
Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome.
Thivakaran A, Botezatu L, Hönes JM, Schütte J, Vassen L, Al-Matary YS, Patnana P, Zeller A, Heuser M, Thol F, Gabdoulline R, Olberding N, Frank D, Suslo M, Köster R, Lennartz K, Görgens A, Giebel B, Opalka B, Dührsen U, Khandanpour C. Thivakaran A, et al. Among authors: schutte j. Haematologica. 2018 Apr;103(4):614-625. doi: 10.3324/haematol.2017.167288. Epub 2018 Jan 11. Haematologica. 2018. PMID: 29326122 Free PMC article.
GFI1 as a novel prognostic and therapeutic factor for AML/MDS.
Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszscak J, Makishima H, Radivoyevitch T, Przychodzen B, da Conceição Castro SV, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G, Dührsen U, Maciejewski JP, Möröy T, Khandanpour C. Hönes JM, et al. Among authors: schutte j. Leukemia. 2016 Jun;30(6):1237-45. doi: 10.1038/leu.2016.11. Epub 2016 Feb 5. Leukemia. 2016. PMID: 26847026
Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML.
Botezatu L, Michel LC, Helness A, Vadnais C, Makishima H, Hönes JM, Robert F, Vassen L, Thivakaran A, Al-Matary Y, Lams RF, Schütte J, Giebel B, Görgens A, Heuser M, Medyouf H, Maciejewski J, Dührsen U, Möröy T, Khandanpour C. Botezatu L, et al. Among authors: schutte j. Exp Hematol. 2016 Aug;44(8):713-726.e14. doi: 10.1016/j.exphem.2016.05.004. Epub 2016 May 20. Exp Hematol. 2016. PMID: 27216773 Free article.
Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner.
Al-Matary YS, Botezatu L, Opalka B, Hönes JM, Lams RF, Thivakaran A, Schütte J, Köster R, Lennartz K, Schroeder T, Haas R, Dührsen U, Khandanpour C. Al-Matary YS, et al. Among authors: schutte j. Haematologica. 2016 Oct;101(10):1216-1227. doi: 10.3324/haematol.2016.143180. Epub 2016 Jul 7. Haematologica. 2016. PMID: 27390361 Free PMC article.
GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.
Marneth AE, Botezatu L, Hönes JM, Israël JCL, Schütte J, Vassen L, Lams RF, Bergevoet SM, Groothuis L, Mandoli A, Martens JHA, Huls G, Jansen JH, Dührsen U, Berg T, Möröy T, Wichmann C, Lo MC, Zhang DE, van der Reijden BA, Khandanpour C. Marneth AE, et al. Among authors: schutte j. Haematologica. 2018 Sep;103(9):e395-e399. doi: 10.3324/haematol.2017.180844. Epub 2018 Apr 19. Haematologica. 2018. PMID: 29674496 Free PMC article. No abstract available.
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.
Barth J, Abou-El-Ardat K, Dalic D, Kurrle N, Maier AM, Mohr S, Schütte J, Vassen L, Greve G, Schulz-Fincke J, Schmitt M, Tosic M, Metzger E, Bug G, Khandanpour C, Wagner SA, Lübbert M, Jung M, Serve H, Schüle R, Berg T. Barth J, et al. Among authors: schutte j. Leukemia. 2019 Jun;33(6):1411-1426. doi: 10.1038/s41375-018-0375-7. Epub 2019 Jan 24. Leukemia. 2019. PMID: 30679800
260 results