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Page 1
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERS, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G, Mousa GA, Wong MY, Ye P, Nagiri RK, Lo I, Holtzman J, Corona C, Yarahmady A, Gill MT, Raju RM, Mok SA, Gong S, Luo W, Zhao M, Tracy TE, Ratan RR, Tsai LH, Sinha SC, Gan L. Udeochu JC, et al. Among authors: carling gk. Nat Neurosci. 2023 May;26(5):737-750. doi: 10.1038/s41593-023-01315-6. Epub 2023 Apr 24. Nat Neurosci. 2023. PMID: 37095396 Free PMC article.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MY, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou Y, Li Y, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, Lee VMY, Gong S, Sinha SC, Dickson DW, Luo W, Gan L. Sayed FA, et al. Among authors: carling gk. Sci Transl Med. 2021 Dec;13(622):eabe3947. doi: 10.1126/scitranslmed.abe3947. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851693 Free PMC article.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
Bravo CP, Giani AM, Perez JM, Zhao Z, Samelson A, Wong MY, Evangelisti A, Fan L, Pozner T, Mercedes M, Ye P, Patel T, Yarahmady A, Carling G, Lee VMY, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L. Bravo CP, et al. bioRxiv [Preprint]. 2023 Jun 22:2023.06.19.544278. doi: 10.1101/2023.06.19.544278. bioRxiv. 2023. Update in: Cell. 2024 May 9;187(10):2446-2464.e22. doi: 10.1016/j.cell.2024.03.015. PMID: 37745431 Free PMC article. Updated. Preprint.
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MY, Zhu D, Yu F, Xu J, Yarahmady A, Chen H, Huang Y, Amin S, Zacharioudakis E, Chen X, Holtzman DM, Mok SA, Gavathiotis E, Sinha SC, Cheng F, Luo W, Gong S, Gan L. Carling GK, et al. bioRxiv [Preprint]. 2024 Jan 25:2024.01.24.577107. doi: 10.1101/2024.01.24.577107. bioRxiv. 2024. Update in: Neuron. 2024 Sep 24:S0896-6273(24)00654-8. doi: 10.1016/j.neuron.2024.09.006. PMID: 38328219 Free PMC article. Updated. Preprint.
Mechanisms of sex differences in Alzheimer's disease.
Lopez-Lee C, Torres ERS, Carling G, Gan L. Lopez-Lee C, et al. Neuron. 2024 Apr 17;112(8):1208-1221. doi: 10.1016/j.neuron.2024.01.024. Epub 2024 Feb 22. Neuron. 2024. PMID: 38402606 Free article. Review.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
Parra Bravo C, Giani AM, Madero-Perez J, Zhao Z, Wan Y, Samelson AJ, Wong MY, Evangelisti A, Cordes E, Fan L, Ye P, Zhu D, Pozner T, Mercedes M, Patel T, Yarahmady A, Carling GK, Sterky FH, Lee VMY, Lee EB, DeTure M, Dickson DW, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L. Parra Bravo C, et al. Among authors: carling gk. Cell. 2024 May 9;187(10):2446-2464.e22. doi: 10.1016/j.cell.2024.03.015. Epub 2024 Apr 5. Cell. 2024. PMID: 38582079 Free article.
12 results