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Page 1
De novo design of protein interactions with learned surface fingerprints.
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE. Gainza P, et al. Among authors: pacesa m. Nature. 2023 May;617(7959):176-184. doi: 10.1038/s41586-023-05993-x. Epub 2023 Apr 26. Nature. 2023. PMID: 37100904 Free PMC article.
PAM-flexible genome editing with an engineered chimeric Cas9.
Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodríguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P. Zhao L, et al. Among authors: pacesa m. Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y. Nat Commun. 2023. PMID: 37794046 Free PMC article.
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: pacesa m. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 36782910
Computational design of soluble and functional membrane protein analogues.
Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, Rosset S, Kapoor S, Choudhury J, Dauparas J, Schellhaas C, Kozlov S, Baker D, Ovchinnikov S, Vecchio AJ, Correia BE. Goverde CA, et al. Among authors: pacesa m. Nature. 2024 Jul;631(8020):449-458. doi: 10.1038/s41586-024-07601-y. Epub 2024 Jun 19. Nature. 2024. PMID: 38898281 Free PMC article.
Computational design of soluble functional analogues of integral membrane proteins.
Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, Rosset S, Kapoor S, Choudhury J, Dauparas J, Schellhaas C, Kozlov S, Baker D, Ovchinnikov S, Vecchio AJ, Correia BE. Goverde CA, et al. Among authors: pacesa m. bioRxiv [Preprint]. 2024 Mar 7:2023.05.09.540044. doi: 10.1101/2023.05.09.540044. bioRxiv. 2024. Update in: Nature. 2024 Jul;631(8020):449-458. doi: 10.1038/s41586-024-07601-y PMID: 38496615 Free PMC article. Updated. Preprint.
21 results