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Ligand and G-protein selectivity in the κ-opioid receptor.
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T. Han J, et al. Among authors: lam jh. Nature. 2023 May;617(7960):417-425. doi: 10.1038/s41586-023-06030-7. Epub 2023 May 3. Nature. 2023. PMID: 37138078 Free PMC article.
Structural basis of the activation of a metabotropic GABA receptor.
Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V. Shaye H, et al. Among authors: lam jh. Nature. 2020 Aug;584(7820):298-303. doi: 10.1038/s41586-020-2408-4. Epub 2020 Jun 17. Nature. 2020. PMID: 32555460 Free PMC article.
Structural basis of GABA reuptake inhibition.
Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C. Motiwala Z, et al. Among authors: lam jh. Nature. 2022 Jun;606(7915):820-826. doi: 10.1038/s41586-022-04814-x. Epub 2022 Jun 8. Nature. 2022. PMID: 35676483 Free PMC article.
Publisher Correction: Structural basis of GABA reuptake inhibition.
Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C. Motiwala Z, et al. Among authors: lam jh. Nature. 2022 Aug;608(7921):E15. doi: 10.1038/s41586-022-05080-7. Nature. 2022. PMID: 35840686 No abstract available.
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket.
Arroyo-Urea S, Nazarova AL, Carrión-Antolí Á, Bonifazi A, Battiti FO, Lam JH, Newman AH, Katritch V, García-Nafría J. Arroyo-Urea S, et al. Among authors: lam jh. Res Sq [Preprint]. 2023 Dec 19:rs.3.rs-3433207. doi: 10.21203/rs.3.rs-3433207/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Sep 5;15(1):7759. doi: 10.1038/s41467-024-51993-4 PMID: 38196573 Free PMC article. Updated. Preprint.
Constitutive activation mechanism of a class C GPCR.
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y. Shin J, et al. Among authors: lam jh. Nat Struct Mol Biol. 2024 Apr;31(4):678-687. doi: 10.1038/s41594-024-01224-7. Epub 2024 Feb 8. Nat Struct Mol Biol. 2024. PMID: 38332368
Structure-Guided Design of Partial Agonists at an Opioid Receptor.
Che T, Varga B, Bernhard SM, El Daibani A, Zaidi S, Lam J, Aguilar J, Appourchaux K, Nazarova A, Kouvelis A, Eans S, Margolis E, Fay J, Pradhan A, Katritch V, McLaughlin J, Majumdar S. Che T, et al. Res Sq [Preprint]. 2024 Jul 16:rs.3.rs-4664764. doi: 10.21203/rs.3.rs-4664764/v1. Res Sq. 2024. PMID: 39070616 Free PMC article. Preprint.
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site.
Arroyo-Urea S, Nazarova AL, Carrión-Antolí Á, Bonifazi A, Battiti FO, Lam JH, Newman AH, Katritch V, García-Nafría J. Arroyo-Urea S, et al. Among authors: lam jh. Nat Commun. 2024 Sep 5;15(1):7759. doi: 10.1038/s41467-024-51993-4. Nat Commun. 2024. PMID: 39237617 Free PMC article.
80 results