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Page 1
Ligand and G-protein selectivity in the κ-opioid receptor.
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T. Han J, et al. Among authors: nazarova al. Nature. 2023 May;617(7960):417-425. doi: 10.1038/s41586-023-06030-7. Epub 2023 May 3. Nature. 2023. PMID: 37138078 Free PMC article.
Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs.
Cunningham MJ, Bock HA, Serrano IC, Bechand B, Vidyadhara DJ, Bonniwell EM, Lankri D, Duggan P, Nazarova AL, Cao AB, Calkins MM, Khirsariya P, Hwu C, Katritch V, Chandra SS, McCorvy JD, Sames D. Cunningham MJ, et al. Among authors: nazarova al. ACS Chem Neurosci. 2023 Jan 4;14(1):119-135. doi: 10.1021/acschemneuro.2c00597. Epub 2022 Dec 15. ACS Chem Neurosci. 2023. PMID: 36521179 Free PMC article.
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.
Bonifazi A, Saab E, Sanchez J, Nazarova AL, Zaidi SA, Jahan K, Katritch V, Canals M, Lane JR, Newman AH. Bonifazi A, et al. Among authors: nazarova al. J Med Chem. 2023 Aug 10;66(15):10304-10341. doi: 10.1021/acs.jmedchem.3c00417. Epub 2023 Jul 19. J Med Chem. 2023. PMID: 37467430 Free PMC article.
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket.
Arroyo-Urea S, Nazarova AL, Carrión-Antolí Á, Bonifazi A, Battiti FO, Lam JH, Newman AH, Katritch V, García-Nafría J. Arroyo-Urea S, et al. Among authors: nazarova al. Res Sq [Preprint]. 2023 Dec 19:rs.3.rs-3433207. doi: 10.21203/rs.3.rs-3433207/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Sep 5;15(1):7759. doi: 10.1038/s41467-024-51993-4 PMID: 38196573 Free PMC article. Updated. Preprint.
Structure-Guided Design of Partial Agonists at an Opioid Receptor.
Che T, Varga B, Bernhard SM, El Daibani A, Zaidi S, Lam J, Aguilar J, Appourchaux K, Nazarova A, Kouvelis A, Eans S, Margolis E, Fay J, Pradhan A, Katritch V, McLaughlin J, Majumdar S. Che T, et al. Res Sq [Preprint]. 2024 Jul 16:rs.3.rs-4664764. doi: 10.21203/rs.3.rs-4664764/v1. Res Sq. 2024. PMID: 39070616 Free PMC article. Preprint.
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site.
Arroyo-Urea S, Nazarova AL, Carrión-Antolí Á, Bonifazi A, Battiti FO, Lam JH, Newman AH, Katritch V, García-Nafría J. Arroyo-Urea S, et al. Among authors: nazarova al. Nat Commun. 2024 Sep 5;15(1):7759. doi: 10.1038/s41467-024-51993-4. Nat Commun. 2024. PMID: 39237617 Free PMC article.
Angiotensin-(1-5) is a Potent Endogenous Angiotensin AT 2 -Receptor Agonist.
Souza-Silva IM, Peluso AA, Elsaafien K, Nazarova AL, Assersen KB, Rodrigues-Ribeiro L, Mohammed M, Rodrigues AF, Nawrocki A, Jakobsen LA, Jensen P, de Kloet AD, Krause EG, Borgo MD, Maslov I, Widdop R, Santos RA, Bader M, Larsen M, Verano-Braga T, Katritch V, Sumners C, Steckelings UM. Souza-Silva IM, et al. Among authors: nazarova al. bioRxiv [Preprint]. 2024 Apr 18:2024.04.05.588367. doi: 10.1101/2024.04.05.588367. bioRxiv. 2024. PMID: 38948791 Free PMC article. Preprint.
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