Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines.
Concato-Lopes VM, Gonçalves-Lens MD, Tomiotto-Pellissier F, Detoni MB, Cruz EMS, Bortoleti BTDS, Carloto ACM, Rodrigues ACJ, Silva TF, Siqueira EDS, de Matos RLN, Alves Cardoso IL, Conchon-Costa I, Lazarin-Bidóia D, Arakawa NS, Dekker RFH, Mantovani MS, Pavanelli WR.
Concato-Lopes VM, et al. Among authors: arakawa ns.
Phytomedicine. 2024 Jun;128:155536. doi: 10.1016/j.phymed.2024.155536. Epub 2024 Mar 13.
Phytomedicine. 2024.
PMID: 38513379