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EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance.
Chibaya L, Murphy KC, DeMarco KD, Gopalan S, Liu H, Parikh CN, Lopez-Diaz Y, Faulkner M, Li J, Morris JP 4th, Ho YJ, Chana SK, Simon J, Luan W, Kulick A, de Stanchina E, Simin K, Zhu LJ, Fazzio TG, Lowe SW, Ruscetti M. Chibaya L, et al. Nat Cancer. 2023 Jun;4(6):872-892. doi: 10.1038/s43018-023-00553-8. Epub 2023 May 4. Nat Cancer. 2023. PMID: 37142692 Free PMC article.
Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer.
Chibaya L, DeMarco KD, Lusi CF, Kane GI, Brassil ML, Parikh CN, Murphy KC, Chowdhury SR, Li J, Ma B, Naylor TE, Cerrutti J, Mori H, Diaz-Infante M, Peura J, Pitarresi JR, Zhu LJ, Fitzgerald KA, Atukorale PU, Ruscetti M. Chibaya L, et al. Sci Transl Med. 2024 Aug 28;16(762):eadj9366. doi: 10.1126/scitranslmed.adj9366. Epub 2024 Aug 28. Sci Transl Med. 2024. PMID: 39196958
Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer.
Chibaya L, Lusi CF, DeMarco KD, Kane GI, Brassil ML, Parikh CN, Murphy KC, Li J, Naylor TE, Cerrutti J, Peura J, Pitarresi JR, Zhu LJ, Fitzgerald KA, Atukorale PU, Ruscetti M. Chibaya L, et al. bioRxiv [Preprint]. 2023 Sep 18:2023.09.18.558307. doi: 10.1101/2023.09.18.558307. bioRxiv. 2023. Update in: Sci Transl Med. 2024 Aug 28;16(762):eadj9366. doi: 10.1126/scitranslmed.adj9366 PMID: 37790484 Free PMC article. Updated. Preprint.