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Page 1
Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis.
Venken K, Jarlborg M, Decruy T, Mortier C, Vlieghe C, Gilis E, De Craemer AS, Coudenys J, Cambré I, Fleury D, Klimowicz A, Van den Bosch F, Hoorens A, Lobaton T, de Roock S, Sparwasser T, Nabozny G, Jacques P, Elewaut D. Venken K, et al. Among authors: gilis e. Ann Rheum Dis. 2023 Aug;82(8):1076-1090. doi: 10.1136/ard-2022-223757. Epub 2023 May 17. Ann Rheum Dis. 2023. PMID: 37197892
Deletion of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis.
Gilis E, Gaublomme D, Staal J, Venken K, Dhaenens M, Lambrecht S, Coudenys J, Decruy T, Schryvers N, Driege Y, Dumas E, Demeyer A, De Muynck A, van Hengel J, Van Hoorebeke L, Deforce D, Beyaert R, Elewaut D. Gilis E, et al. Arthritis Rheumatol. 2019 Dec;71(12):2005-2015. doi: 10.1002/art.41029. Epub 2019 Nov 9. Arthritis Rheumatol. 2019. PMID: 31259485
RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells.
Mortier C, Gracey E, Coudenys J, Manuello T, Decruy T, Maelegheer M, Stappers F, Gilis E, Gaublomme D, Van Hoorebeke L, Van Welden S, Ambler C, Hegen M, Symanowicz P, Steyn S, Berstein G, Elewaut D, Venken K. Mortier C, et al. Among authors: gilis e. Rheumatology (Oxford). 2023 Sep 1;62(9):3169-3178. doi: 10.1093/rheumatology/kead022. Rheumatology (Oxford). 2023. PMID: 36661300
Sterile triggers drive joint inflammation in TNF- and IL-1β-dependent mouse arthritis models.
Thiran A, Petta I, Blancke G, Thorp M, Planckaert G, Jans M, Andries V, Barbry K, Gilis E, Coudenys J, Hochepied T, Vanhove C, Gracey E, Dumas E, Manuelo T, Josipovic I, van Loo G, Elewaut D, Vereecke L. Thiran A, et al. Among authors: gilis e. EMBO Mol Med. 2023 Oct 11;15(10):e17691. doi: 10.15252/emmm.202317691. Epub 2023 Sep 11. EMBO Mol Med. 2023. PMID: 37694693 Free PMC article.
Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice.
Van Damme KFA, Hertens P, Martens A, Gilis E, Priem D, Bruggeman I, Fossoul A, Declercq J, Aegerter H, Wullaert A, Hochepied T, Hoste E, Vande Walle L, Lamkanfi M, Savvides SN, Elewaut D, Lambrecht BN, van Loo G. Van Damme KFA, et al. Among authors: gilis e. Sci Rep. 2023 Oct 21;13(1):17992. doi: 10.1038/s41598-023-45324-8. Sci Rep. 2023. PMID: 37865713 Free PMC article.
Intestinal epithelial expression of human TNF is sufficient to induce small bowel inflammation and sacroiliitis mimicking human Spondyloarthritis.
Debusschere K, Souza D, Nabozny GH, Dumas E, Verheugen E, Coudenys J, Manuello T, Stappers F, Decruy T, Maelegheer M, Schryvers N, Gilis E, Elewaut D. Debusschere K, et al. Among authors: gilis e. Rheumatology (Oxford). 2024 Sep 18:keae507. doi: 10.1093/rheumatology/keae507. Online ahead of print. Rheumatology (Oxford). 2024. PMID: 39292604