Zhuang CL - Search Results

1

Compound-42 alleviates acute kidney injury by targeting RIPK3-mediated necroptosis.

He XY, Wang F, Suo XG, Gu MZ, Wang JN, Xu CH, Dong YH, He Y, Zhang Y, Ji ML, Chen Y, Zhang MM, Fan YG, Wen JG, Jin J, Wang J, Li J, Zhuang CL, Liu MM, Meng XM. He XY, et al. Among authors: zhuang cl. Br J Pharmacol. 2023 Oct;180(20):2641-2660. doi: 10.1111/bph.16152. Epub 2023 Jul 1. Br J Pharmacol. 2023. PMID: 37248964 Free article.

2

Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3.

Chen X, Zhuang C, Ren Y, Zhang H, Qin X, Hu L, Fu J, Miao Z, Chai Y, Liu ZG, Zhang H, Cai Z, Wang HY. Chen X, et al. Br J Pharmacol. 2019 Jun;176(12):2095-2108. doi: 10.1111/bph.14653. Epub 2019 May 6. Br J Pharmacol. 2019. PMID: 30825190 Free PMC article.

3

The Bcr-Abl inhibitor GNF-7 inhibits necroptosis and ameliorates acute kidney injury by targeting RIPK1 and RIPK3 kinases.

Qin X, Hu L, Shi SN, Chen X, Zhuang C, Zhang W, Jitkaew S, Pang X, Yu J, Tan YX, Wang HY, Cai Z. Qin X, et al. Biochem Pharmacol. 2020 Jul;177:113947. doi: 10.1016/j.bcp.2020.113947. Epub 2020 Apr 2. Biochem Pharmacol. 2020. PMID: 32247850

4

Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.

Zhu J, Xin M, Xu C, He Y, Zhang W, Wang Z, Zhuang C. Zhu J, et al. Acta Pharm Sin B. 2021 Oct;11(10):3193-3205. doi: 10.1016/j.apsb.2021.05.017. Epub 2021 May 24. Acta Pharm Sin B. 2021. PMID: 34729309 Free PMC article.

5

Targeting Necroptosis as a Promising Therapy for Alzheimer's Disease.

Zhao W, Liu Y, Xu L, He Y, Cai Z, Yu J, Zhang W, Xing C, Zhuang C, Qu Z. Zhao W, et al. ACS Chem Neurosci. 2022 Jun 15;13(12):1697-1713. doi: 10.1021/acschemneuro.2c00172. Epub 2022 May 23. ACS Chem Neurosci. 2022. PMID: 35607807 Review.

6

Identification of a marine-derived sesquiterpenoid, Compound-8, that inhibits tumour necrosis factor-induced cell death by blocking complex II assembly.

He Y, Yang T, Li J, Li K, Zhuang C, Zhang M, Li R, Zhao Y, Song Q, Jiang M, Mao S, Song XG, Guo Y, Li X, Tan F, Jitkaew S, Zhang W, Cai Z. He Y, et al. Br J Pharmacol. 2024 Aug;181(15):2443-2458. doi: 10.1111/bph.16364. Epub 2024 Mar 31. Br J Pharmacol. 2024. PMID: 38555910

7

The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis.

Rui C, Shi SN, Ren W, Qin X, Zhuang C, Chen X, Chen G, Yu J, Wang HY, Cai Z. Rui C, et al. Biochem Pharmacol. 2021 Jun;188:114542. doi: 10.1016/j.bcp.2021.114542. Epub 2021 Apr 2. Biochem Pharmacol. 2021. PMID: 33819469

8

Targeting Receptor-Interacting Protein Kinase 1 by Novel Benzothiazole Derivatives: Treatment of Acute Lung Injury through the Necroptosis Pathway.

Zhang X, Han Q, Hou R, Xu L, Zhang W, Xing C, Xue L, Zhuang C. Zhang X, et al. J Med Chem. 2023 Apr 13;66(7):5261-5278. doi: 10.1021/acs.jmedchem.3c00197. Epub 2023 Mar 12. J Med Chem. 2023. PMID: 36908007

9

Osteoclastogenesis Inhibitory Polyketides from the Sponge-Associated Fungus Xylaria feejeensis.

Wang J, Xu CC, Tang H, Su L, Chou Y, Soong K, Li J, Zhuang CL, Luo YP, Zhang W. Wang J, et al. Among authors: zhuang cl. Chem Biodivers. 2018 Dec;15(12):e1800358. doi: 10.1002/cbdv.201800358. Epub 2018 Dec 5. Chem Biodivers. 2018. PMID: 30295992

10

N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK-632) Analogues as Novel Necroptosis Inhibitors by Targeting Receptor-Interacting Protein Kinase 3 (RIPK3): Synthesis, Structure-Activity Relationships, and in Vivo Efficacy.

Zhang H, Xu L, Qin X, Chen X, Cong H, Hu L, Chen L, Miao Z, Zhang W, Cai Z, Zhuang C. Zhang H, et al. J Med Chem. 2019 Jul 25;62(14):6665-6681. doi: 10.1021/acs.jmedchem.9b00611. Epub 2019 May 28. J Med Chem. 2019. PMID: 31095385

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