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Ketolysis drives CD8+ T cell effector function through effects on histone acetylation.
Luda KM, Longo J, Kitchen-Goosen SM, Duimstra LR, Ma EH, Watson MJ, Oswald BM, Fu Z, Madaj Z, Kupai A, Dickson BM, DeCamp LM, Dahabieh MS, Compton SE, Teis R, Kaymak I, Lau KH, Kelly DP, Puchalska P, Williams KS, Krawczyk CM, Lévesque D, Boisvert FM, Sheldon RD, Rothbart SB, Crawford PA, Jones RG. Luda KM, et al. Among authors: sheldon rd. Immunity. 2023 Sep 12;56(9):2021-2035.e8. doi: 10.1016/j.immuni.2023.07.002. Epub 2023 Jul 28. Immunity. 2023. PMID: 37516105 Free PMC article.
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1.
Zhao Y, Liu Z, Liu G, Zhang Y, Liu S, Gan D, Chang W, Peng X, Sung ES, Gilbert K, Zhu Y, Wang X, Zeng Z, Baldwin H, Ren G, Weaver J, Huron A, Mayberry T, Wang Q, Wang Y, Diaz-Rubio ME, Su X, Stack MS, Zhang S, Lu X, Sheldon RD, Li J, Zhang C, Wan J, Lu X. Zhao Y, et al. Cell Metab. 2023 Oct 3;35(10):1688-1703.e10. doi: 10.1016/j.cmet.2023.09.004. Cell Metab. 2023. PMID: 37793345 Free PMC article.
Dietary Restriction Enhances CD8⁺ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity.
Oswald BM, DeCamp LM, Longo J, Dahabieh MS, Bunda N, Ma S, Watson MJ, Sheldon RD, Vincent MP, Johnson BK, Ellis AE, Soper-Hopper MT, Isaguirre CN, Shen H, Williams KS, Crawford PA, Kaech S, Jang HJ, Krawczyk CM, Jones RG. Oswald BM, et al. Among authors: sheldon rd. bioRxiv [Preprint]. 2024 Nov 15:2024.11.14.621733. doi: 10.1101/2024.11.14.621733. bioRxiv. 2024. PMID: 39605550 Free PMC article. Preprint.
693 results