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Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway.
Lau JK, Brown KC, Dom AM, Witte TR, Thornhill BA, Crabtree CM, Perry HE, Brown JM, Ball JG, Creel RG, Damron CL, Rollyson WD, Stevenson CD, Hardman WE, Valentovic MA, Carpenter AB, Dasgupta P. Lau JK, et al. Among authors: brown kc, brown jm. Apoptosis. 2014 Aug;19(8):1190-201. doi: 10.1007/s10495-014-1007-y. Apoptosis. 2014. PMID: 24878626 Free PMC article.
Bioavailability of capsaicin and its implications for drug delivery.
Rollyson WD, Stover CA, Brown KC, Perry HE, Stevenson CD, McNees CA, Ball JG, Valentovic MA, Dasgupta P. Rollyson WD, et al. Among authors: brown kc. J Control Release. 2014 Dec 28;196:96-105. doi: 10.1016/j.jconrel.2014.09.027. Epub 2014 Oct 12. J Control Release. 2014. PMID: 25307998 Free PMC article. Review.
Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway.
Friedman JR, Perry HE, Brown KC, Gao Y, Lin J, Stevenson CD, Hurley JD, Nolan NA, Akers AT, Chen YC, Denning KL, Brown LG, Dasgupta P. Friedman JR, et al. Among authors: brown kc, brown lg. Biochem Pharmacol. 2017 Apr 1;129:54-66. doi: 10.1016/j.bcp.2017.01.004. Epub 2017 Jan 16. Biochem Pharmacol. 2017. PMID: 28104436 Free PMC article.
Anticancer Activity of Natural and Synthetic Capsaicin Analogs.
Friedman JR, Nolan NA, Brown KC, Miles SL, Akers AT, Colclough KW, Seidler JM, Rimoldi JM, Valentovic MA, Dasgupta P. Friedman JR, et al. Among authors: brown kc. J Pharmacol Exp Ther. 2018 Mar;364(3):462-473. doi: 10.1124/jpet.117.243691. Epub 2017 Dec 15. J Pharmacol Exp Ther. 2018. PMID: 29246887 Free PMC article. Review.
Capsaicinoids enhance chemosensitivity to chemotherapeutic drugs.
Friedman JR, Richbart SD, Merritt JC, Perry HE, Brown KC, Akers AT, Nolan NA, Stevenson CD, Hurley JD, Miles SL, Tirona MT, Valentovic MA, Dasgupta P. Friedman JR, et al. Among authors: brown kc. Adv Cancer Res. 2019;144:263-298. doi: 10.1016/bs.acr.2019.05.002. Adv Cancer Res. 2019. PMID: 31349900 Review.
Nonpungent N-AVAM Capsaicin Analogues and Cancer Therapy.
Richbart SD, Friedman JR, Brown KC, Gadepalli RS, Miles SL, Rimoldi JM, Rankin GO, Valentovic MA, Tirona MT, Finch PT, Hess JA, Dasgupta P. Richbart SD, et al. Among authors: brown kc. J Med Chem. 2021 Feb 11;64(3):1346-1361. doi: 10.1021/acs.jmedchem.0c01679. Epub 2021 Jan 28. J Med Chem. 2021. PMID: 33508189 Free PMC article.
182 results