Humphry M - Search Results

1

Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production.

Burzynski LC, Morales-Maldonado A, Rodgers A, Kitt LA, Humphry M, Figg N, Bennett MR, Clarke MCH. Burzynski LC, et al. Among authors: humphry m. Cardiovasc Res. 2023 Oct 16;119(12):2179-2189. doi: 10.1093/cvr/cvad091. Cardiovasc Res. 2023. PMID: 37309666 Free PMC article.

2

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation.

Zheng Y, Humphry M, Maguire JJ, Bennett MR, Clarke MC. Zheng Y, et al. Among authors: humphry m. Immunity. 2013 Feb 21;38(2):285-95. doi: 10.1016/j.immuni.2013.01.008. Epub 2013 Feb 7. Immunity. 2013. PMID: 23395675 Free PMC article.

3

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype.

Gardner SE, Humphry M, Bennett MR, Clarke MC. Gardner SE, et al. Among authors: humphry m. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1963-74. doi: 10.1161/ATVBAHA.115.305896. Epub 2015 Jul 2. Arterioscler Thromb Vasc Biol. 2015. PMID: 26139463 Free PMC article.

4

Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.

Burzynski LC, Humphry M, Bennett MR, Clarke MC. Burzynski LC, et al. Among authors: humphry m. J Biol Chem. 2015 Oct 9;290(41):25188-96. doi: 10.1074/jbc.M115.667915. Epub 2015 Aug 31. J Biol Chem. 2015. PMID: 26324711 Free PMC article.

5

IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype.

Wiggins KA, Parry AJ, Cassidy LD, Humphry M, Webster SJ, Goodall JC, Narita M, Clarke MCH. Wiggins KA, et al. Among authors: humphry m. Aging Cell. 2019 Jun;18(3):e12946. doi: 10.1111/acel.12946. Epub 2019 Mar 27. Aging Cell. 2019. PMID: 30916891 Free PMC article.

6

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.

Burzynski LC, Humphry M, Pyrillou K, Wiggins KA, Chan JNE, Figg N, Kitt LL, Summers C, Tatham KC, Martin PB, Bennett MR, Clarke MCH. Burzynski LC, et al. Among authors: humphry m. Immunity. 2019 Apr 16;50(4):1033-1042.e6. doi: 10.1016/j.immuni.2019.03.003. Epub 2019 Mar 26. Immunity. 2019. PMID: 30926232 Free PMC article.

7

Cell surface IL-1α trafficking is specifically inhibited by interferon-γ, and associates with the membrane via IL-1R2 and GPI anchors.

Chan JNE, Humphry M, Kitt L, Krzyzanska D, Filbey KJ, Bennett MR, Clarke MCH. Chan JNE, et al. Among authors: humphry m. Eur J Immunol. 2020 Nov;50(11):1663-1675. doi: 10.1002/eji.201948521. Epub 2020 Jun 8. Eur J Immunol. 2020. PMID: 32447774 Free article.

8

The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells.

Wiggins KA, Pyrillou K, Humphry M, Butterworth AS, Clarke MC. Wiggins KA, et al. Among authors: humphry m. Immunology. 2023 Mar;168(3):459-472. doi: 10.1111/imm.13584. Epub 2022 Oct 13. Immunology. 2023. PMID: 36175368 Free PMC article.

9

Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.

Morales-Maldonado A, Humphry M, Figg N, Clarke MC. Morales-Maldonado A, et al. Among authors: humphry m. Atherosclerosis. 2024 Mar;390:117308. doi: 10.1016/j.atherosclerosis.2023.117308. Epub 2023 Sep 28. Atherosclerosis. 2024. PMID: 37821269 Free article.

10

Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.

Pyrillou K, Humphry M, Kitt LA, Rodgers A, Nus M, Bennett MR, Smith KG, Lyons PA, Mallat Z, Clarke MC. Pyrillou K, et al. Among authors: humphry m. JCI Insight. 2024 Feb 8;9(5):e174005. doi: 10.1172/jci.insight.174005. JCI Insight. 2024. PMID: 38329807 Free PMC article.

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