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Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration.
Lee S, Roest ASV, Blair CA, Kao K, Bremner SB, Childers MC, Pathak D, Heinrich P, Lee D, Chirikian O, Mohran S, Roberts B, Smith JE, Jahng JW, Paik DT, Wu JC, Gunawardane RN, Spudich JA, Ruppel K, Mack D, Pruitt BL, Regnier M, Wu SM, Bernstein D. Lee S, et al. Among authors: regnier m. bioRxiv [Preprint]. 2023 Jun 9:2023.06.08.544276. doi: 10.1101/2023.06.08.544276. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318413121. doi: 10.1073/pnas.2318413121 PMID: 37333118 Free PMC article. Updated. Preprint.
Modulation of post-powerstroke dynamics in myosin II by 2'-deoxy-ADP.
Childers MC, Geeves M, Daggett V, Regnier M. Childers MC, et al. Among authors: regnier m. Arch Biochem Biophys. 2021 Mar 15;699:108733. doi: 10.1016/j.abb.2020.108733. Epub 2020 Dec 31. Arch Biochem Biophys. 2021. PMID: 33388313 Free PMC article.
Conformational sampling of CMT-2D associated GlyRS mutations.
Childers MC, Regnier M, Bothwell M, Smith AST. Childers MC, et al. Among authors: regnier m. Brain Multiphys. 2022;3:100054. doi: 10.1016/j.brain.2022.100054. Epub 2022 Sep 6. Brain Multiphys. 2022. PMID: 36504507 Free PMC article.
Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle.
Kooiker KB, Mohran S, Turner KL, Ma W, Flint G, Qi L, Gao C, Zheng Y, McMillen TS, Mandrycky C, Martinson A, Mahoney-Schaefer M, Freeman JC, Costales Arenas EG, Tu AY, Irving TC, Geeves MA, Tanner BCW, Regnier M, Davis J, Moussavi-Harami F. Kooiker KB, et al. Among authors: regnier m. bioRxiv [Preprint]. 2023 Feb 3:2023.01.31.526380. doi: 10.1101/2023.01.31.526380. bioRxiv. 2023. Update in: Circ Res. 2023 Aug 18;133(5):430-443. doi: 10.1161/CIRCRESAHA.123.322629 PMID: 36778318 Free PMC article. Updated. Preprint.
Atomistic Simulations of Sarcomere Proteins.
Childers MC, Regnier M. Childers MC, et al. Among authors: regnier m. Methods Mol Biol. 2024;2735:27-41. doi: 10.1007/978-1-0716-3527-8_3. Methods Mol Biol. 2024. PMID: 38038842
Far-red and sensitive sensor for monitoring real time H2O2 dynamics with subcellular resolution and in multi-parametric imaging applications.
Lee JD, Nguyen A, Jin ZR, Moghadasi A, Gibbs CE, Wait SJ, Evitts KM, Asencio A, Bremner SB, Zuniga S, Chavan V, Williams A, Smith N, Regnier M, Young JE, Mack D, Nance E, Boyle PM, Berndt A. Lee JD, et al. Among authors: regnier m. bioRxiv [Preprint]. 2024 Feb 8:2024.02.06.579232. doi: 10.1101/2024.02.06.579232. bioRxiv. 2024. PMID: 38370715 Free PMC article. Preprint.
MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy.
Steczina S, Mohran S, Bailey LRJ, McMillen TS, Kooiker KB, Wood NB, Davis J, Previs MJ, Olivotto I, Pioner JM, Geeves MA, Poggesi C, Regnier M. Steczina S, et al. Among authors: regnier m. J Mol Cell Cardiol. 2024 Jun;191:27-39. doi: 10.1016/j.yjmcc.2024.04.010. Epub 2024 Apr 20. J Mol Cell Cardiol. 2024. PMID: 38648963
373 results