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IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system.
Seyedsadr M, Wang Y, Elzoheiry M, Shree Gopal S, Jang S, Duran G, Chervoneva I, Kasimoglou E, Wrobel JA, Hwang D, Garifallou J, Zhang X, Khan TH, Lorenz U, Su M, Ting JP, Broux B, Rostami A, Miskin D, Markovic-Plese S. Seyedsadr M, et al. Among authors: broux b. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2221007120. doi: 10.1073/pnas.2221007120. Epub 2023 Jun 20. Proc Natl Acad Sci U S A. 2023. PMID: 37339207 Free PMC article.
Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.
Hermans D, Houben E, Baeten P, Slaets H, Janssens K, Hoeks C, Hosseinkhani B, Duran G, Bormans S, Gowing E, Hoornaert C, Beckers L, Fung WK, Schroten H, Ishikawa H, Fraussen J, Thoelen R, de Vries HE, Kooij G, Zandee S, Prat A, Hellings N, Broux B. Hermans D, et al. Among authors: broux b. Acta Neuropathol. 2022 Aug;144(2):259-281. doi: 10.1007/s00401-022-02445-0. Epub 2022 Jun 6. Acta Neuropathol. 2022. PMID: 35666306
Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood - brain barrier function.
Hosseinkhani B, Duran G, Hoeks C, Hermans D, Schepers M, Baeten P, Poelmans J, Coenen B, Bekar K, Pintelon I, Timmermans JP, Vanmierlo T, Michiels L, Hellings N, Broux B. Hosseinkhani B, et al. Among authors: broux b. Fluids Barriers CNS. 2023 Dec 19;20(1):95. doi: 10.1186/s12987-023-00504-6. Fluids Barriers CNS. 2023. PMID: 38114994 Free PMC article.
Effect on neutrophil migration and antimicrobial functions by the Bruton's tyrosine kinase inhibitors tolebrutinib, evobrutinib and fenebrutinib.
De Bondt M, Renders J, de Prado PP, Berghmans N, Pörtner N, Vanbrabant L, de Oliveira VLS, Duran G, Baeten P, Broux B, Gouwy M, Matthys P, Hellings N, Struyf S. De Bondt M, et al. Among authors: broux b. J Leukoc Biol. 2024 Jul 8:qiae160. doi: 10.1093/jleuko/qiae160. Online ahead of print. J Leukoc Biol. 2024. PMID: 38976501
Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination.
Houben E, Janssens K, Hermans D, Vandooren J, Van den Haute C, Schepers M, Vanmierlo T, Lambrichts I, van Horssen J, Baekelandt V, Opdenakker G, Baron W, Broux B, Slaets H, Hellings N. Houben E, et al. Among authors: broux b. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):5028-5038. doi: 10.1073/pnas.1912910117. Epub 2020 Feb 18. Proc Natl Acad Sci U S A. 2020. PMID: 32071226 Free PMC article.
Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation.
Spaas J, Franssen WMA, Keytsman C, Blancquaert L, Vanmierlo T, Bogie J, Broux B, Hellings N, van Horssen J, Posa DK, Hoetker D, Baba SP, Derave W, Eijnde BO. Spaas J, et al. Among authors: broux b. J Neuroinflammation. 2021 Nov 5;18(1):255. doi: 10.1186/s12974-021-02306-9. J Neuroinflammation. 2021. PMID: 34740381 Free PMC article.
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