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Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection.
Rathnasinghe R, Strohmeier S, Amanat F, Gillespie VL, Krammer F, García-Sastre A, Coughlan L, Schotsaert M, Uccellini M. Rathnasinghe R, et al. bioRxiv [Preprint]. 2020 Jul 6:2020.07.06.190066. doi: 10.1101/2020.07.06.190066. bioRxiv. 2020. Update in: Emerg Microbes Infect. 2020 Dec;9(1):2433-2445. doi: 10.1080/22221751.2020.1838955 PMID: 32676603 Free PMC article. Updated. Preprint.
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, Chang MW, Chan JF, Cao J, Poon VK, Herbert KM, Cheng K, Nguyen TH, Rubanov A, Pu Y, Nguyen C, Choi A, Rathnasinghe R, Schotsaert M, Miorin L, Dejosez M, Zwaka TP, Sit KY, Martinez-Sobrido L, Liu WC, White KM, Chapman ME, Lendy EK, Glynne RJ, Albrecht R, Ruppin E, Mesecar AD, Johnson JR, Benner C, Sun R, Schultz PG, Su AI, García-Sastre A, Chatterjee AK, Yuen KY, Chanda SK. Riva L, et al. Among authors: rathnasinghe r. Nature. 2020 Oct;586(7827):113-119. doi: 10.1038/s41586-020-2577-1. Epub 2020 Jul 24. Nature. 2020. PMID: 32707573 Free PMC article.
Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model.
Amanat F, Strohmeier S, Rathnasinghe R, Schotsaert M, Coughlan L, García-Sastre A, Krammer F. Amanat F, et al. Among authors: rathnasinghe r. bioRxiv [Preprint]. 2020 Sep 17:2020.09.16.300970. doi: 10.1101/2020.09.16.300970. bioRxiv. 2020. Update in: mBio. 2021 Mar 2;12(2):e02648-20. doi: 10.1128/mBio.02648-20 PMID: 32995785 Free PMC article. Updated. Preprint.
Scalable, effective, and rapid decontamination of SARS-CoV-2 contaminated N95 respirators using germicidal ultra-violet C (UVC) irradiation device.
Rathnasinghe R, Karlicek RF, Schotsaert M, Koffas MA, Arduini B, Jangra S, Wang B, Davis JL, Alnaggar M, Costa A, Vincent R, Garcia-Sastre A, Vashishth D, Balchandani P. Rathnasinghe R, et al. medRxiv [Preprint]. 2020 Oct 6:2020.10.05.20206953. doi: 10.1101/2020.10.05.20206953. medRxiv. 2020. Update in: Sci Rep. 2021 Oct 7;11(1):19970. doi: 10.1038/s41598-021-99431-5 PMID: 33052360 Free PMC article. Updated. Preprint.
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Miorin L, Kehrer T, Sanchez-Aparicio MT, Zhang K, Cohen P, Patel RS, Cupic A, Makio T, Mei M, Moreno E, Danziger O, White KM, Rathnasinghe R, Uccellini M, Gao S, Aydillo T, Mena I, Yin X, Martin-Sancho L, Krogan NJ, Chanda SK, Schotsaert M, Wozniak RW, Ren Y, Rosenberg BR, Fontoura BMA, García-Sastre A. Miorin L, et al. Among authors: rathnasinghe r. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28344-28354. doi: 10.1073/pnas.2016650117. Epub 2020 Oct 23. Proc Natl Acad Sci U S A. 2020. PMID: 33097660 Free PMC article.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.
Jangra S, De Vrieze J, Choi A, Rathnasinghe R, Laghlali G, Uvyn A, Van Herck S, Nuhn L, Deswarte K, Zhong Z, Sanders N, Lienenklaus S, David S, Strohmeier S, Amanat F, Krammer F, Hammad H, Lambrecht BN, Coughlan L, García-Sastre A, De Geest BG, Schotsaert M. Jangra S, et al. Among authors: rathnasinghe r. bioRxiv [Preprint]. 2020 Oct 23:2020.10.23.344085. doi: 10.1101/2020.10.23.344085. bioRxiv. 2020. Update in: Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9467-9473. doi: 10.1002/anie.202015362 PMID: 33106810 Free PMC article. Updated. Preprint.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*.
Jangra S, De Vrieze J, Choi A, Rathnasinghe R, Laghlali G, Uvyn A, Van Herck S, Nuhn L, Deswarte K, Zhong Z, Sanders NN, Lienenklaus S, David SA, Strohmeier S, Amanat F, Krammer F, Hammad H, Lambrecht BN, Coughlan L, García-Sastre A, De Geest BG, Schotsaert M. Jangra S, et al. Among authors: rathnasinghe r. Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9467-9473. doi: 10.1002/anie.202015362. Epub 2021 Mar 11. Angew Chem Int Ed Engl. 2021. PMID: 33464672 Free PMC article.
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A. White KM, et al. Among authors: rathnasinghe r. Science. 2021 Feb 26;371(6532):926-931. doi: 10.1126/science.abf4058. Epub 2021 Jan 25. Science. 2021. PMID: 33495306 Free PMC article.
51 results