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Page 1
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
Dimou E, Katsinelos T, Meisl G, Tuck BJ, Keeling S, Smith AE, Hidari E, Lam JYL, Burke M, Lövestam S, Ranasinghe RT, McEwan WA, Klenerman D. Dimou E, et al. Among authors: lovestam s. Cell Rep. 2023 Jul 25;42(7):112725. doi: 10.1016/j.celrep.2023.112725. Epub 2023 Jul 1. Cell Rep. 2023. PMID: 37393617 Free PMC article.
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lövestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW. Yang Y, et al. Among authors: lovestam s. Acta Neuropathol. 2023 Mar;145(3):325-333. doi: 10.1007/s00401-022-02533-1. Epub 2023 Jan 7. Acta Neuropathol. 2023. PMID: 36611124 Free PMC article.
Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.
Tarutani A, Lövestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M. Tarutani A, et al. Among authors: lovestam s. FEBS Open Bio. 2023 Aug;13(8):1394-1404. doi: 10.1002/2211-5463.13657. Epub 2023 Jul 7. FEBS Open Bio. 2023. PMID: 37337995 Free PMC article.
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lövestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW. Schweighauser M, et al. Among authors: lovestam s. Nature. 2022 May;605(7909):310-314. doi: 10.1038/s41586-022-04650-z. Epub 2022 Mar 28. Nature. 2022. PMID: 35344985 Free PMC article.
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy.
Lövestam S, Koh FA, van Knippenberg B, Kotecha A, Murzin AG, Goedert M, Scheres SHW. Lövestam S, et al. Elife. 2022 Mar 4;11:e76494. doi: 10.7554/eLife.76494. Elife. 2022. PMID: 35244536 Free PMC article.
Many neurodegenerative diseases, including Alzheimer's disease, the most common form of dementia, are characterised by knotted clumps of a protein called tau. ...This is largely because researchers making tau proteins in the lab have yet to replicate the exact structure of …
Many neurodegenerative diseases, including Alzheimer's disease, the most common form of dementia, are characterised by knotted clumps …
New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy.
Yang Y, Garringer HJ, Shi Y, Lövestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M. Yang Y, et al. Among authors: lovestam s. Acta Neuropathol. 2023 May;145(5):561-572. doi: 10.1007/s00401-023-02550-8. Epub 2023 Feb 27. Acta Neuropathol. 2023. PMID: 36847833 Free PMC article.
Correction: Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems.
Bacioglu M, Bacioglu M, Gray D, Lövestam S, Katsinelos T, Quaegebeur A, van Swieten J, Jaunmuktane Z, Davies SW, Scheres SHW, Goedert M, Ghetti B, Spillantini MG. Bacioglu M, et al. Among authors: lovestam s. Acta Neuropathol Commun. 2024 Aug 14;12(1):131. doi: 10.1186/s40478-024-01842-8. Acta Neuropathol Commun. 2024. PMID: 39138552 Free PMC article. No abstract available.
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems.
Bacioglu M, Schweighauser M, Gray D, Lövestam S, Katsinelos T, Quaegebeur A, van Swieten J, Jaunmuktane Z, Davies SW, Scheres SHW, Goedert M, Ghetti B, Spillantini MG. Bacioglu M, et al. Among authors: lovestam s. Acta Neuropathol Commun. 2024 Jun 17;12(1):99. doi: 10.1186/s40478-024-01813-z. Acta Neuropathol Commun. 2024. PMID: 38886865 Free PMC article.
14 results