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Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
Dimou E, Katsinelos T, Meisl G, Tuck BJ, Keeling S, Smith AE, Hidari E, Lam JYL, Burke M, Lövestam S, Ranasinghe RT, McEwan WA, Klenerman D. Dimou E, et al. Among authors: mcewan wa. Cell Rep. 2023 Jul 25;42(7):112725. doi: 10.1016/j.celrep.2023.112725. Epub 2023 Jul 1. Cell Rep. 2023. PMID: 37393617 Free PMC article.
Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric-Aβ mediates pathology maturation.
Darricau M, Dou C, Kinet R, Zhu T, Zhou L, Li X, Bedel A, Claverol S, Tokarski C, Katsinelos T, McEwan WA, Zhang L, Gao R, Bourdenx M, Dehay B, Qin C, Bezard E, Planche V. Darricau M, et al. Among authors: mcewan wa. Alzheimers Dement. 2024 Mar;20(3):1894-1912. doi: 10.1002/alz.13604. Epub 2023 Dec 26. Alzheimers Dement. 2024. PMID: 38148705 Free PMC article.
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function.
Miller LVC, Papa G, Vaysburd M, Cheng S, Sweeney PW, Smith A, Franco C, Katsinelos T, Huang M, Sanford SAI, Benn J, Farnsworth J, Higginson K, Joyner H, McEwan WA, James LC. Miller LVC, et al. Among authors: mcewan wa. Cell. 2024 Oct 17;187(21):5967-5980.e17. doi: 10.1016/j.cell.2024.08.024. Epub 2024 Sep 13. Cell. 2024. PMID: 39276772 Free PMC article.
Aggregate-selective removal of pathological tau by clustering-activated degraders.
Benn J, Cheng S, Keeling S, Smith AE, Vaysburd MJ, Böken D, Miller LVC, Katsinelos T, Franco C, Dupré E, Danis C, Landrieu I, Buée L, Klenerman D, James LC, McEwan WA. Benn J, et al. Among authors: mcewan wa. Science. 2024 Aug 30;385(6712):1009-1016. doi: 10.1126/science.adp5186. Epub 2024 Aug 29. Science. 2024. PMID: 39208111 Free PMC article.
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Mukadam AS, Miller LVC, Smith AE, Vaysburd M, Sakya SA, Sanford S, Keeling S, Tuck BJ, Katsinelos T, Green C, Skov L, Kaalund SS, Foss S, Mayes K, O'Connell K, Wing M, Knox C, Banbury J, Avezov E, Rowe JB, Goedert M, Andersen JT, James LC, McEwan WA. Mukadam AS, et al. Among authors: mcewan wa. Science. 2023 Mar 31;379(6639):1336-1341. doi: 10.1126/science.abn1366. Epub 2023 Mar 30. Science. 2023. PMID: 36996217 Free PMC article.
46 results