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Page 1
Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
Le K, Soth MJ, Cross JB, Liu G, Ray WJ, Ma J, Goodwani SG, Acton PJ, Buggia-Prevot V, Akkermans O, Barker J, Conner ML, Jiang Y, Liu Z, McEwan P, Warner-Schmidt J, Xu A, Zebisch M, Heijnen CJ, Abrahams B, Jones P. Le K, et al. Among authors: acton pj. J Med Chem. 2023 Jul 27;66(14):9954-9971. doi: 10.1021/acs.jmedchem.3c00788. Epub 2023 Jul 12. J Med Chem. 2023. PMID: 37436942
Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments.
Ma J, Goodwani S, Acton PJ, Buggia-Prevot V, Kesler SR, Jamal I, Mahant ID, Liu Z, Mseeh F, Roth BL, Chakraborty C, Peng B, Wu Q, Jiang Y, Le K, Soth MJ, Jones P, Kavelaars A, Ray WJ, Heijnen CJ. Ma J, et al. Among authors: acton pj. Pain. 2021 Oct 1;162(10):2599-2612. doi: 10.1097/j.pain.0000000000002256. Pain. 2021. PMID: 33872235 Free PMC article.
Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons.
Shughrue PJ, Acton PJ, Breese RS, Zhao WQ, Chen-Dodson E, Hepler RW, Wolfe AL, Matthews M, Heidecker GJ, Joyce JG, Villarreal SA, Kinney GG. Shughrue PJ, et al. Among authors: acton pj. Neurobiol Aging. 2010 Feb;31(2):189-202. doi: 10.1016/j.neurobiolaging.2008.04.003. Neurobiol Aging. 2010. PMID: 18486276
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers.
De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL. De Felice FG, et al. Among authors: acton pj. Neurobiol Aging. 2008 Sep;29(9):1334-47. doi: 10.1016/j.neurobiolaging.2007.02.029. Epub 2007 Apr 2. Neurobiol Aging. 2008. PMID: 17403556 Free PMC article.