Canals M - Search Results

1

Assessment of the potential of novel and classical opioids to induce respiratory depression in mice.

Hill R, Sanchez J, Lemel L, Antonijevic M, Hosking Y, Mistry SN, Kruegel AC, Javitch JA, Lane JR, Canals M. Hill R, et al. Among authors: canals m. Br J Pharmacol. 2023 Dec;180(24):3160-3174. doi: 10.1111/bph.16199. Epub 2023 Aug 22. Br J Pharmacol. 2023. PMID: 37489013 Free PMC article.

2

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

Jenkins L, Alvarez-Curto E, Campbell K, de Munnik S, Canals M, Schlyer S, Milligan G. Jenkins L, et al. Among authors: canals m. Br J Pharmacol. 2011 Feb;162(3):733-48. doi: 10.1111/j.1476-5381.2010.01082.x. Br J Pharmacol. 2011. PMID: 20958291 Free PMC article.

3

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A. Canals M, et al. J Biol Chem. 2012 Jan 2;287(1):650-659. doi: 10.1074/jbc.M111.314278. Epub 2011 Nov 15. J Biol Chem. 2012. PMID: 22086918 Free PMC article.

4

Sequential conformational rearrangements dictate the dynamics of class C GPCR activation.

Lane JR, Canals M. Lane JR, et al. Among authors: canals m. Sci Signal. 2012 Nov 20;5(251):pe51. doi: 10.1126/scisignal.2003503. Sci Signal. 2012. PMID: 23169816

5

Allosteric modulation of a chemogenetically modified G protein-coupled receptor.

Abdul-Ridha A, Lane JR, Sexton PM, Canals M, Christopoulos A. Abdul-Ridha A, et al. Among authors: canals m. Mol Pharmacol. 2013 Feb;83(2):521-30. doi: 10.1124/mol.112.083006. Epub 2012 Nov 29. Mol Pharmacol. 2013. PMID: 23197649

6

Regulation of G protein-coupled receptors by allosteric ligands.

Lane JR, Abdul-Ridha A, Canals M. Lane JR, et al. Among authors: canals m. ACS Chem Neurosci. 2013 Apr 17;4(4):527-34. doi: 10.1021/cn400005t. Epub 2013 Feb 21. ACS Chem Neurosci. 2013. PMID: 23398684 Free PMC article. Review.

7

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors.

Lane JR, Chubukov P, Liu W, Canals M, Cherezov V, Abagyan R, Stevens RC, Katritch V. Lane JR, et al. Among authors: canals m. Mol Pharmacol. 2013 Dec;84(6):794-807. doi: 10.1124/mol.113.088054. Epub 2013 Sep 10. Mol Pharmacol. 2013. PMID: 24021214 Free PMC article.

8

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.

Abdul-Ridha A, López L, Keov P, Thal DM, Mistry SN, Sexton PM, Lane JR, Canals M, Christopoulos A. Abdul-Ridha A, et al. Among authors: canals m. J Biol Chem. 2014 Feb 28;289(9):6067-79. doi: 10.1074/jbc.M113.539080. Epub 2014 Jan 17. J Biol Chem. 2014. PMID: 24443568 Free PMC article.

9

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.

Yeatman HR, Lane JR, Choy KH, Lambert NA, Sexton PM, Christopoulos A, Canals M. Yeatman HR, et al. Among authors: canals m. J Biol Chem. 2014 May 30;289(22):15856-66. doi: 10.1074/jbc.M113.536672. Epub 2014 Apr 21. J Biol Chem. 2014. PMID: 24753247 Free PMC article.

10

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.

Abdul-Ridha A, Lane JR, Mistry SN, López L, Sexton PM, Scammells PJ, Christopoulos A, Canals M. Abdul-Ridha A, et al. Among authors: canals m. J Biol Chem. 2014 Nov 28;289(48):33701-11. doi: 10.1074/jbc.M114.604967. Epub 2014 Oct 17. J Biol Chem. 2014. PMID: 25326383 Free PMC article.

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