Qu Z - Search Results

1

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.

Liang S, Tran E, Du X, Dong J, Sudholz H, Chen H, Qu Z, Huntington ND, Babon JJ, Kershaw NJ, Zhang ZY, Baell JB, Wiede F, Tiganis T. Liang S, et al. Among authors: qu z. Nat Commun. 2023 Jul 27;14(1):4524. doi: 10.1038/s41467-023-40170-8. Nat Commun. 2023. PMID: 37500611 Free PMC article.

2

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.

Dong J, Miao J, Miao Y, Qu Z, Zhang S, Zhu P, Wiede F, Jassim BA, Bai Y, Nguyen Q, Lin J, Chen L, Tiganis T, Tao WA, Zhang ZY. Dong J, et al. Among authors: qu z. Angew Chem Int Ed Engl. 2023 May 22;62(22):e202303818. doi: 10.1002/anie.202303818. Epub 2023 Apr 21. Angew Chem Int Ed Engl. 2023. PMID: 36973833 Free PMC article.

3

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.

Liang S, Tran E, Du X, Dong J, Sudholz H, Chen H, Qu Z, Huntington N, Babon J, Kershaw N, Zhang ZY, Baell J, Wiede F, Tiganis T. Liang S, et al. Among authors: qu z. bioRxiv [Preprint]. 2023 Jun 28:2023.06.16.545220. doi: 10.1101/2023.06.16.545220. bioRxiv. 2023. Update in: Nat Commun. 2023 Jul 27;14(1):4524. doi: 10.1038/s41467-023-40170-8. PMID: 37397992 Free PMC article. Updated. Preprint.

4

Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity.

Miao J, Bai Y, Miao Y, Qu Z, Dong J, Zhang RY, Aggarwal D, Jassim BA, Nguyen Q, Zhang ZY. Miao J, et al. Among authors: qu z. Molecules. 2023 Oct 6;28(19):6947. doi: 10.3390/molecules28196947. Molecules. 2023. PMID: 37836790 Free PMC article.

5

Discovery of a selective TC-PTP degrader for cancer immunotherapy.

Miao J, Dong J, Miao Y, Bai Y, Qu Z, Jassim BA, Huang B, Nguyen Q, Ma Y, Murray AA, Li J, Low PS, Zhang ZY. Miao J, et al. Among authors: qu z. Chem Sci. 2023 Oct 24;14(44):12606-12614. doi: 10.1039/d3sc04541b. eCollection 2023 Nov 15. Chem Sci. 2023. PMID: 38020389 Free PMC article.

6

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy.

Qu Z, Dong J, Zhang ZY. Qu Z, et al. Br J Pharmacol. 2023 Dec 20:10.1111/bph.16304. doi: 10.1111/bph.16304. Online ahead of print. Br J Pharmacol. 2023. PMID: 38116815 Review.

7

High-Throughput Discovery and Characterization of Covalent Inhibitors for Protein Tyrosine Phosphatases.

Qu Z, Krabill AD, Zhang ZY. Qu Z, et al. Methods Mol Biol. 2024;2743:301-316. doi: 10.1007/978-1-0716-3569-8_19. Methods Mol Biol. 2024. PMID: 38147223

8

Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase.

Liang W, Krabill AD, Gallagher KS, Muli C, Qu Z, Trader D, Zhang ZY, Dai M. Liang W, et al. Among authors: qu z. Tetrahedron. 2024 Apr 28;156:133918. doi: 10.1016/j.tet.2024.133918. Epub 2024 Mar 2. Tetrahedron. 2024. PMID: 38618612

9

Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.

Dong J, Jassim BA, Milholland KL, Qu Z, Bai Y, Miao Y, Miao J, Ma Y, Lin J, Hall MC, Zhang ZY. Dong J, et al. Among authors: qu z. J Med Chem. 2024 Jun 13;67(11):8817-8835. doi: 10.1021/acs.jmedchem.4c00149. Epub 2024 May 20. J Med Chem. 2024. PMID: 38768084

10

Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers.

Miao Y, Bai Y, Miao J, Murray AA, Lin J, Dong J, Qu Z, Zhang RY, Nguyen QD, Wang S, Yu J, Nguele Meke F, Zhang ZY. Miao Y, et al. Among authors: qu z. J Clin Invest. 2024 Jun 6;134(15):e177142. doi: 10.1172/JCI177142. J Clin Invest. 2024. PMID: 38842946 Free PMC article.

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