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Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure.
Ence CC, Uddin T, Borrel J, Mittal P, Xie H, Zoller J, Sharma A, Comer E, Schreiber SL, Melillo B, Sibley LD, Chatterjee AK. Ence CC, et al. Among authors: comer e. bioRxiv [Preprint]. 2024 Feb 28:2024.02.28.582607. doi: 10.1101/2024.02.28.582607. bioRxiv. 2024. Update in: ACS Infect Dis. 2024 Jun 14;10(6):2212-2221. doi: 10.1021/acsinfecdis.4c00170. PMID: 38464220 Free PMC article. Updated. Preprint.
The genetic legacy of African Americans from Catoctin Furnace.
Harney É, Micheletti S, Bruwelheide KS, Freyman WA, Bryc K, Akbari A, Jewett E, Comer E, Gates HL Jr, Heywood L, Thornton J, Curry R, Esselmann SA, Barca KG, Sedig J, Sirak K, Olalde I, Adamski N, Bernardos R, Broomandkhoshbacht N, Ferry M, Qiu L, Stewardson K, Workman JN, Zalzala F, Mallick S, Micco A, Mah M, Zhang Z; 23andMe Research Team†; Rohland N, Mountain JL, Owsley DW, Reich D; 23andMe Research Team. Harney É, et al. Among authors: comer e. Science. 2023 Aug 4;381(6657):eade4995. doi: 10.1126/science.ade4995. Epub 2023 Aug 4. Science. 2023. PMID: 37535739 Free PMC article.
Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase.
Vinayak S, Jumani RS, Miller P, Hasan MM, McLeod BI, Tandel J, Stebbins EE, Teixeira JE, Borrel J, Gonse A, Zhang M, Yu X, Wernimont A, Walpole C, Eckley S, Love MS, McNamara CW, Sharma M, Sharma A, Scherer CA, Kato N, Schreiber SL, Melillo B, Striepen B, Huston CD, Comer E. Vinayak S, et al. Among authors: comer e. Sci Transl Med. 2020 Sep 30;12(563):eaba8412. doi: 10.1126/scitranslmed.aba8412. Sci Transl Med. 2020. PMID: 32998973 Free PMC article.
Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells.
Nagiec MM, Duvall JR, Skepner AP, Howe EA, Bastien J, Comer E, Marie JC, Johnston SE, Negri J, Eichhorn M, Vantourout J, Clish C, Musunuru K, Foley M, Perez JR, Palmer MAJ. Nagiec MM, et al. Among authors: comer e. Medchemcomm. 2018 Sep 14;9(11):1831-1842. doi: 10.1039/c8md00297e. eCollection 2018 Nov 1. Medchemcomm. 2018. PMID: 30542533 Free PMC article.
Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures.
Mortison JD, Schenone M, Myers JA, Zhang Z, Chen L, Ciarlo C, Comer E, Natchiar SK, Carr SA, Klaholz BP, Myers AG. Mortison JD, et al. Among authors: comer e. Cell Chem Biol. 2018 Dec 20;25(12):1506-1518.e13. doi: 10.1016/j.chembiol.2018.09.010. Epub 2018 Oct 11. Cell Chem Biol. 2018. PMID: 30318461 Free PMC article.
44 results