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A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.
Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook AW, Bauer M, Hoffmann HH, Pinharanda A, Ricardo-Lax I, Stenzel AF, Rosado-Olivieri EA, Dinnon KH 3rd, Doyle WC, Freije CA, Hong SH, Lee D, Lewy T, Luna JM, Peace A, Schmidt C, Schneider WM, Winkler R, Yip EZ, Larson C, McGinn T, Menezes MR, Ramos-Espiritu L, Banerjee P, Poirier JT, Sànchez-Rivera FJ, Cobat A, Zhang Q, Casanova JL, Carroll TS, Glickman JF, Michailidis E, Razooky B, MacDonald MR, Rice CM. Le Pen J, et al. Among authors: glickman jf. PLoS Biol. 2024 Sep 24;22(9):e3002767. doi: 10.1371/journal.pbio.3002767. eCollection 2024 Sep. PLoS Biol. 2024. PMID: 39316623 Free PMC article.
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055.
Michino M, Khan TA, Miller MW, Fukase Y, Vendome J, Adura C, Glickman JF, Liu Y, Wan L, Allis CD, Stamford AW, Meinke PT, Renzetti LM, Kargman S, Liverton NJ, Huggins DJ. Michino M, et al. Among authors: glickman jf. ACS Med Chem Lett. 2024 Mar 12;15(4):524-532. doi: 10.1021/acsmedchemlett.4c00016. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628784
High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease.
Krumm CS, Landzberg RS, Ramos-Espiritu L, Adura C, Liu X, Acuna M, Xie Y, Xu X, Tillman MC, Li Y, Glickman JF, Ortlund EA, Ginn JD, Cohen DE. Krumm CS, et al. Among authors: glickman jf. Mol Metab. 2023 Dec;78:101832. doi: 10.1016/j.molmet.2023.101832. Epub 2023 Oct 30. Mol Metab. 2023. PMID: 38403978 Free PMC article.
Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Xie W, Lama L, Yang X, Kuryavyi V, Bhattacharya S, Nudelman I, Yang G, Ouerfelli O, Glickman JF, Jones RA, Tuschl T, Patel DJ. Xie W, et al. Among authors: glickman jf. Cell Chem Biol. 2023 Nov 16;30(11):1366-1376.e7. doi: 10.1016/j.chembiol.2023.07.002. Epub 2023 Aug 2. Cell Chem Biol. 2023. PMID: 37536341 Free PMC article.
Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.
Lavin RC, Johnson C, Ahn YM, Kremiller KM, Sherwood M, Patel JS, Pan Y, Russo R, MacGilvary NJ, Giacalone D, Kevorkian YL, Zimmerman MD, Glickman JF, Freundlich JS, Tan S. Lavin RC, et al. Among authors: glickman jf. PLoS Biol. 2021 Jul 28;19(7):e3001355. doi: 10.1371/journal.pbio.3001355. eCollection 2021 Jul. PLoS Biol. 2021. PMID: 34319985 Free PMC article.
Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening.
Lalazar G, Requena D, Ramos-Espiritu L, Ng D, Bhola PD, de Jong YP, Wang R, Narayan NJC, Shebl B, Levin S, Michailidis E, Kabbani M, Vercauteren KOA, Hurley AM, Farber BA, Hammond WJ, Saltsman JA 3rd, Weinberg EM, Glickman JF, Lyons BA, Ellison J, Schadde E, Hertl M, Leiting JL, Truty MJ, Smoot RL, Tierney F, Kato T, Wendel HG, LaQuaglia MP, Rice CM, Letai A, Coffino P, Torbenson MS, Ortiz MV, Simon SM. Lalazar G, et al. Among authors: glickman jf. Cancer Discov. 2021 Oct;11(10):2544-2563. doi: 10.1158/2159-8290.CD-20-0872. Epub 2021 Jun 14. Cancer Discov. 2021. PMID: 34127480 Free PMC article.
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG. Minuesa G, et al. Among authors: glickman jf. Nat Commun. 2019 Jun 19;10(1):2691. doi: 10.1038/s41467-019-10523-3. Nat Commun. 2019. PMID: 31217428 Free PMC article.
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano Y, Hashizume S, Aida J, Imaeda T, Okamoto R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinke P, Glickman JF, Patel DJ, Tuschl T. Lama L, et al. Among authors: glickman jf. Nat Commun. 2019 May 21;10(1):2261. doi: 10.1038/s41467-019-08620-4. Nat Commun. 2019. PMID: 31113940 Free PMC article.
51 results