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Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Xie W, Lama L, Yang X, Kuryavyi V, Bhattacharya S, Nudelman I, Yang G, Ouerfelli O, Glickman JF, Jones RA, Tuschl T, Patel DJ. Xie W, et al. Among authors: ouerfelli o. Cell Chem Biol. 2023 Nov 16;30(11):1366-1376.e7. doi: 10.1016/j.chembiol.2023.07.002. Epub 2023 Aug 2. Cell Chem Biol. 2023. PMID: 37536341 Free PMC article.
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.
Oskarsson T, Nagorny P, Krauss IJ, Perez L, Mandal M, Yang G, Ouerfelli O, Xiao D, Moore MA, Massagué J, Danishefsky SJ. Oskarsson T, et al. Among authors: ouerfelli o. J Am Chem Soc. 2010 Mar 10;132(9):3224-8. doi: 10.1021/ja9101503. J Am Chem Soc. 2010. PMID: 20155906 Free PMC article.
Inhibition of human peptide deformylase disrupts mitochondrial function.
Escobar-Alvarez S, Gardner J, Sheth A, Manfredi G, Yang G, Ouerfelli O, Heaney ML, Scheinberg DA. Escobar-Alvarez S, et al. Among authors: ouerfelli o. Mol Cell Biol. 2010 Nov;30(21):5099-109. doi: 10.1128/MCB.00469-10. Epub 2010 Aug 30. Mol Cell Biol. 2010. PMID: 20805355 Free PMC article.
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.
Somwar R, Erdjument-Bromage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus HE. Somwar R, et al. Among authors: ouerfelli o. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80. doi: 10.1073/pnas.1113554108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930909 Free PMC article.
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.
Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O, Unser M, Schnappinger D, McKinney J, Nathan C. Vaubourgeix J, et al. Among authors: ouerfelli o. Cell Host Microbe. 2015 Feb 11;17(2):178-90. doi: 10.1016/j.chom.2014.12.008. Epub 2015 Jan 22. Cell Host Microbe. 2015. PMID: 25620549 Free PMC article.
74 results