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345 results

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Page 1
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F. Pérez-Vargas J, et al. Among authors: leduc r. Emerg Microbes Infect. 2023 Dec;12(2):2246594. doi: 10.1080/22221751.2023.2246594. Emerg Microbes Infect. 2023. PMID: 37555275 Free PMC article.
Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics.
Pérez-Vargas J, Shapira T, Olmstead AD, Villanueva I, Thompson CAH, Ennis S, Gao G, De Guzman J, Williams DE, Wang M, Chin A, Bautista-Sánchez D, Agafitei O, Levett P, Xie X, Nuzzo G, Freire VF, Quintana-Bulla JI, Bernardi DI, Gubiani JR, Suthiphasilp V, Raksat A, Meesakul P, Polbuppha I, Cheenpracha S, Jaidee W, Kanokmedhakul K, Yenjai C, Chaiyosang B, Teles HL, Manzo E, Fontana A, Leduc R, Boudreault PL, Berlinck RGS, Laphookhieo S, Kanokmedhakul S, Tietjen I, Cherkasov A, Krajden M, Nabi IR, Niikura M, Shi PY, Andersen RJ, Jean F. Pérez-Vargas J, et al. Among authors: leduc r. Antiviral Res. 2023 Jan;209:105484. doi: 10.1016/j.antiviral.2022.105484. Epub 2022 Dec 8. Antiviral Res. 2023. PMID: 36503013 Free PMC article.
Corrigendum to "Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics" "Antiviral Research 209 (2023)/105484".
Perez-Vargas J, Shapira T, Olmstead AD, Villanueva I, Thompson CAH, Ennis S, Gao G, De Guzman J, Williams DE, Wang M, Chin A, Bautista-Sanchez D, Agafitei O, Levett P, Xie X, Nuzzo G, Freire VF, Quintana-Bulla JI, Bernardi DI, Gubiani JR, Suthiphasilp V, Raksat A, Meesakul P, Polbuppha I, Cheenpracha S, Jaidee W, Kanokmedhakul K, Yenjai C, Chaiyosang B, Teles HL, Manzo E, Fontana A, Leduc R, Boudreault PL, Berlinck RGS, Laphookhieo S, Kanokmedhakul S, Tietjen I, Cherkasov A, Krajden M, Nabi IR, Niikura M, Shi PY, Andersen RJ, Jean F. Perez-Vargas J, et al. Among authors: leduc r. Antiviral Res. 2023 May;213:105577. doi: 10.1016/j.antiviral.2023.105577. Epub 2023 Mar 30. Antiviral Res. 2023. PMID: 37002158 Free PMC article. No abstract available.
Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals.
Pérez-Vargas J, Lemieux G, Thompson CAH, Désilets A, Ennis S, Gao G, Gordon DG, Schulz AL, Niikura M, Nabi IR, Krajden M, Boudreault PL, Leduc R, Jean F. Pérez-Vargas J, et al. Among authors: leduc r. Antiviral Res. 2024 May;225:105869. doi: 10.1016/j.antiviral.2024.105869. Epub 2024 Mar 26. Antiviral Res. 2024. PMID: 38548023 Free article.
Diabetic Deformities of the Lesser Toes.
LeDuc R, Pinzur MS. LeDuc R, et al. Foot Ankle Clin. 2024 Dec;29(4):645-650. doi: 10.1016/j.fcl.2023.12.005. Epub 2024 Jan 17. Foot Ankle Clin. 2024. PMID: 39448177 Review.
The urotensin II receptor triggers an early meningeal response and a delayed macrophage-dependent vasospasm after subarachnoid hemorrhage in male mice.
Pedard M, Prevost L, Carpena C, Holleran B, Desrues L, Dubois M, Nicola C, Gruel R, Godefroy D, Deffieux T, Tanter M, Ali C, Leduc R, Prézeau L, Gandolfo P, Morin F, Wurtz O, Bonnard T, Vivien D, Castel H. Pedard M, et al. Among authors: leduc r. Nat Commun. 2024 Sep 29;15(1):8430. doi: 10.1038/s41467-024-52654-2. Nat Commun. 2024. PMID: 39341842 Free PMC article.
G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.
Jallouli R, Moreno Salinas AL, Laniel A, Holleran B, Avet C, Jacob J, Hoang T, Lavoie C, Carmon KS, Bouvier M, Leduc R. Jallouli R, et al. Among authors: leduc r. Res Sq [Preprint]. 2024 Sep 5:rs.3.rs-4869264. doi: 10.21203/rs.3.rs-4869264/v1. Res Sq. 2024. Update in: Cell Mol Life Sci. 2024 Sep 4;81(1):383. doi: 10.1007/s00018-024-05416-8 PMID: 39281883 Free PMC article. Updated. Preprint.
345 results