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A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F. Pérez-Vargas J, et al. Among authors: smith jr. Emerg Microbes Infect. 2023 Dec;12(2):2246594. doi: 10.1080/22221751.2023.2246594. Emerg Microbes Infect. 2023. PMID: 37555275 Free PMC article.
Targeting SARS-CoV-2 papain-like protease in the postvaccine era.
Ton AT, Pandey M, Smith JR, Ban F, Fernandez M, Cherkasov A. Ton AT, et al. Among authors: smith jr. Trends Pharmacol Sci. 2022 Nov;43(11):906-919. doi: 10.1016/j.tips.2022.08.008. Epub 2022 Aug 24. Trends Pharmacol Sci. 2022. PMID: 36114026 Free PMC article. Review.
5,182 results