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248 results

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The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.
Toscan CE, McCalmont H, Ashoorzadeh A, Lin X, Fu Z, Doculara L, Kosasih HJ, Cadiz R, Zhou A, Williams S, Evans K, Khalili F, Cai R, Yeats KL, Gifford AJ, Pickford R, Mayoh C, Xie J, Henderson MJ, Trahair TN, Patterson AV, Smaill JB, de Bock CE, Lock RB. Toscan CE, et al. Among authors: henderson mj. Blood Cancer J. 2024 Nov 6;14(1):192. doi: 10.1038/s41408-024-01180-x. Blood Cancer J. 2024. PMID: 39505850 Free PMC article.
High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease.
Williams D, Glasstetter LM, Jong TT, Chen T, Kapoor A, Zhu S, Zhu Y, Calvo R, Gehrlein A, Wong K, Hogan AN, Vocadlo DJ, Jagasia R, Marugan JJ, Sidransky E, Henderson MJ, Chen Y. Williams D, et al. Among authors: henderson mj. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2406009121. doi: 10.1073/pnas.2406009121. Epub 2024 Oct 10. Proc Natl Acad Sci U S A. 2024. PMID: 39388267 Free PMC article.
Fatty Acid Derivatization and Cyclization of the Immunomodulatory Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor Activity.
Singh SS, Calvo R, Kumari A, Sable RV, Fang Y, Tao D, Hu X, Castle SG, Nahar S, Li D, Major E, Sanchez TW, Kato R, Xu X, Zhou J, Liu L, LeClair CA, Simeonov A, Baljinnyam B, Henderson MJ, Marugan J, Rudloff U. Singh SS, et al. Among authors: henderson mj. Mol Cancer Ther. 2024 Dec 3;23(12):1827-1841. doi: 10.1158/1535-7163.MCT-23-0790. Mol Cancer Ther. 2024. PMID: 39212669
Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease.
Williams D, Glasstetter LM, Jong TT, Kapoor A, Zhu S, Zhu Y, Gehrlein A, Vocadlo DJ, Jagasia R, Marugan JJ, Sidransky E, Henderson MJ, Chen Y. Williams D, et al. Among authors: henderson mj. bioRxiv [Preprint]. 2024 Mar 27:2024.03.22.586364. doi: 10.1101/2024.03.22.586364. bioRxiv. 2024. PMID: 38712038 Free PMC article. Preprint.
Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice.
Chandía-Cristi A, Gutiérrez DA, Dulcey AE, Lara M, Vargas L, Lin YH, Jimenez-Muñoz P, Larenas G, Xu X, Wang A, Owens A, Dextras C, Chen Y, Pinto C, Marín T, Almarza-Salazar H, Acevedo K, Cancino GI, Hu X, Rojas P, Ferrer M, Southall N, Henderson MJ, Zanlungo S, Marugan JJ, Álvarez R A. Chandía-Cristi A, et al. Among authors: henderson mj. Cell Rep. 2024 May 28;43(5):114144. doi: 10.1016/j.celrep.2024.114144. Epub 2024 Apr 23. Cell Rep. 2024. PMID: 38656874 Free PMC article.
Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis.
Ippolitov D, Lin YH, Spence J, Glogowska A, Thanasupawat T, Beiko J, Del Bigio MR, Xu X, Wang A, Calvo R, Kapoor A, Marugan JJ, Henderson MJ, Klonisch T, Hombach-Klonisch S. Ippolitov D, et al. Among authors: henderson mj. bioRxiv [Preprint]. 2024 Feb 22:2024.02.19.581073. doi: 10.1101/2024.02.19.581073. bioRxiv. 2024. PMID: 38529509 Free PMC article. Preprint.
FDA-approved disulfiram as a novel treatment for aggressive leukemia.
Karsa M, Xiao L, Ronca E, Bongers A, Spurling D, Karsa A, Cantilena S, Mariana A, Failes TW, Arndt GM, Cheung LC, Kotecha RS, Sutton R, Lock RB, Williams O, de Boer J, Haber M, Norris MD, Henderson MJ, Somers K. Karsa M, et al. Among authors: henderson mj. J Mol Med (Berl). 2024 Apr;102(4):507-519. doi: 10.1007/s00109-023-02414-4. Epub 2024 Feb 13. J Mol Med (Berl). 2024. PMID: 38349407 Free PMC article.
248 results