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Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF. Mitterreiter S, et al. Among authors: lichtenthaler sf. J Neurosci. 2010 Jun 30;30(26):8974-83. doi: 10.1523/JNEUROSCI.1199-10.2010. J Neurosci. 2010. PMID: 20592218 Free PMC article.
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S. Baranger K, et al. Among authors: lichtenthaler sf. Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23. Cell Mol Life Sci. 2016. PMID: 26202697 Free PMC article.
195 results