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A Designed Approach to Enantiodivergent Enamine Catalysis.
Macharia J, Wambua V, Hong Y, Harris L, Hirschi JS, Evans GB, Vetticatt MJ. Macharia J, et al. Angew Chem Int Ed Engl. 2017 Jul 17;56(30):8756-8760. doi: 10.1002/anie.201703919. Epub 2017 Jun 20. Angew Chem Int Ed Engl. 2017. PMID: 28544165
E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.
Godwin TD, Kelly ST, Brew TP, Bougen-Zhukov NM, Single AB, Chen A, Stylianou CE, Harris LD, Currie SK, Telford BJ, Beetham HG, Evans GB, Black MA, Guilford PJ. Godwin TD, et al. Among authors: harris ld. Gastric Cancer. 2019 Mar;22(2):273-286. doi: 10.1007/s10120-018-0859-1. Epub 2018 Jul 31. Gastric Cancer. 2019. PMID: 30066183 Free PMC article.
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single molecule perspective.
Seifert M, Bera SC, van Nies P, Kirchdoerfer RN, Shannon A, Le TT, Meng X, Xia H, Wood JM, Harris LD, Papini FS, Arnold JJ, Almo SC, Grove TL, Shi PY, Xiang Y, Canard B, Depken M, Cameron CE, Dulin D. Seifert M, et al. Among authors: harris ld. bioRxiv [Preprint]. 2021 Apr 8:2020.08.06.240325. doi: 10.1101/2020.08.06.240325. bioRxiv. 2021. Update in: Elife. 2021 Oct 07;10:e70968. doi: 10.7554/eLife.70968 PMID: 33851161 Free PMC article. Updated. Preprint.
Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP.
Wood JM, Evans GB, Grove TL, Almo SC, Cameron SA, Furneaux RH, Harris LD. Wood JM, et al. Among authors: harris ld. J Org Chem. 2021 Jul 2;86(13):8843-8850. doi: 10.1021/acs.joc.1c00761. Epub 2021 Jun 14. J Org Chem. 2021. PMID: 34126010
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective.
Seifert M, Bera SC, van Nies P, Kirchdoerfer RN, Shannon A, Le TT, Meng X, Xia H, Wood JM, Harris LD, Papini FS, Arnold JJ, Almo S, Grove TL, Shi PY, Xiang Y, Canard B, Depken M, Cameron CE, Dulin D. Seifert M, et al. Among authors: harris ld. Elife. 2021 Oct 7;10:e70968. doi: 10.7554/eLife.70968. Elife. 2021. PMID: 34617885 Free PMC article.
115 results