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Page 1
Structure-Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin.
Skowron KJ, Baliga C, Johnson T, Kremiller KM, Castroverde A, Dean TT, Allen AC, Lopez-Hernandez AM, Aleksandrova EV, Klepacki D, Mankin AS, Polikanov YS, Moore TW. Skowron KJ, et al. Among authors: klepacki d. J Med Chem. 2023 Sep 14;66(17):11831-11842. doi: 10.1021/acs.jmedchem.3c00406. Epub 2023 Aug 21. J Med Chem. 2023. PMID: 37603874 Free PMC article.
Selection of small peptides, inhibitors of translation.
Llano-Sotelo B, Klepacki D, Mankin AS. Llano-Sotelo B, et al. Among authors: klepacki d. J Mol Biol. 2009 Sep 4;391(5):813-9. doi: 10.1016/j.jmb.2009.06.069. Epub 2009 Jul 2. J Mol Biol. 2009. PMID: 19576904 Free PMC article.
Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.
Vázquez-Laslop N, Klepacki D, Mulhearn DC, Ramu H, Krasnykh O, Franzblau S, Mankin AS. Vázquez-Laslop N, et al. Among authors: klepacki d. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10496-501. doi: 10.1073/pnas.1103474108. Epub 2011 Jun 13. Proc Natl Acad Sci U S A. 2011. PMID: 21670252 Free PMC article.
Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.
Martínez AK, Gordon E, Sengupta A, Shirole N, Klepacki D, Martinez-Garriga B, Brown LM, Benedik MJ, Yanofsky C, Mankin AS, Vazquez-Laslop N, Sachs MS, Cruz-Vera LR. Martínez AK, et al. Among authors: klepacki d. Nucleic Acids Res. 2014 Jan;42(2):1245-56. doi: 10.1093/nar/gkt923. Epub 2013 Oct 16. Nucleic Acids Res. 2014. PMID: 24137004 Free PMC article.
Macrolide antibiotics allosterically predispose the ribosome for translation arrest.
Sothiselvam S, Liu B, Han W, Ramu H, Klepacki D, Atkinson GC, Brauer A, Remm M, Tenson T, Schulten K, Vázquez-Laslop N, Mankin AS. Sothiselvam S, et al. Among authors: klepacki d. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9804-9. doi: 10.1073/pnas.1403586111. Epub 2014 Jun 24. Proc Natl Acad Sci U S A. 2014. PMID: 24961372 Free PMC article.
48 results