Chen Y - Search Results

1

Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8⁺ T cells.

Mahadevan KK, LeBleu VS, Ramirez EV, Chen Y, Li B, Sockwell AM, Gagea M, Sugimoto H, Sthanam LK, Tampe D, Zeisberg M, Ying H, Jain AK, DePinho RA, Maitra A, McAndrews KM, Kalluri R. Mahadevan KK, et al. Among authors: chen y. Dev Cell. 2023 Sep 11;58(17):1562-1577.e8. doi: 10.1016/j.devcel.2023.07.025. Epub 2023 Aug 24. Dev Cell. 2023. PMID: 37625403 Free PMC article.

2

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program.

Chen Y, LeBleu VS, Carstens JL, Sugimoto H, Zheng X, Malasi S, Saur D, Kalluri R. Chen Y, et al. EMBO Mol Med. 2018 Oct;10(10):e9085. doi: 10.15252/emmm.201809085. EMBO Mol Med. 2018. PMID: 30120146 Free PMC article.

3

Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis.

Chen Y, Keskin D, Sugimoto H, Kanasaki K, Phillips PE, Bizarro L, Sharpe A, LeBleu VS, Kalluri R. Chen Y, et al. PLoS Biol. 2018 Dec 28;16(12):e2005907. doi: 10.1371/journal.pbio.2005907. eCollection 2018 Dec. PLoS Biol. 2018. PMID: 30592710 Free PMC article.

4

Stromal Cells Exhibit Prevalent Genetic Aberrations in Colorectal Cancer.

McAndrews KM, Chen Y, Kalluri R. McAndrews KM, et al. Among authors: chen y. Cancer Cell. 2020 Dec 14;38(6):774-775. doi: 10.1016/j.ccell.2020.11.003. Cancer Cell. 2020. PMID: 33321084 Free article.

5

Type I collagen deletion in αSMA⁺ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer.

Chen Y, Kim J, Yang S, Wang H, Wu CJ, Sugimoto H, LeBleu VS, Kalluri R. Chen Y, et al. Cancer Cell. 2021 Apr 12;39(4):548-565.e6. doi: 10.1016/j.ccell.2021.02.007. Epub 2021 Mar 4. Cancer Cell. 2021. PMID: 33667385 Free PMC article.

6

Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis.

Tang M, Chen Y, Li B, Sugimoto H, Yang S, Yang C, LeBleu VS, McAndrews KM, Kalluri R. Tang M, et al. Among authors: chen y. FASEB J. 2021 May;35(5):e21557. doi: 10.1096/fj.202002777RR. FASEB J. 2021. PMID: 33855751 Free PMC article.

7

Clinical and therapeutic relevance of cancer-associated fibroblasts.

Chen Y, McAndrews KM, Kalluri R. Chen Y, et al. Nat Rev Clin Oncol. 2021 Dec;18(12):792-804. doi: 10.1038/s41571-021-00546-5. Epub 2021 Sep 6. Nat Rev Clin Oncol. 2021. PMID: 34489603 Free PMC article. Review.

8

Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta.

Chen Y, Yang S, Lovisa S, Ambrose CG, McAndrews KM, Sugimoto H, Kalluri R. Chen Y, et al. Nat Commun. 2021 Dec 10;12(1):7199. doi: 10.1038/s41467-021-27563-3. Nat Commun. 2021. PMID: 34893625 Free PMC article.

9

Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer.

McAndrews KM, Chen Y, Darpolor JK, Zheng X, Yang S, Carstens JL, Li B, Wang H, Miyake T, Correa de Sampaio P, Kirtley ML, Natale M, Wu CC, Sugimoto H, LeBleu VS, Kalluri R. McAndrews KM, et al. Among authors: chen y. Cancer Discov. 2022 Jun 2;12(6):1580-1597. doi: 10.1158/2159-8290.CD-20-1484. Cancer Discov. 2022. PMID: 35348629 Free PMC article.

10

Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer.

Chen Y, Yang S, Tavormina J, Tampe D, Zeisberg M, Wang H, Mahadevan KK, Wu CJ, Sugimoto H, Chang CC, Jenq RR, McAndrews KM, Kalluri R. Chen Y, et al. Cancer Cell. 2022 Aug 8;40(8):818-834.e9. doi: 10.1016/j.ccell.2022.06.011. Epub 2022 Jul 21. Cancer Cell. 2022. PMID: 35868307 Free PMC article.

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