Kholodenko BN - Search Results

1

A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression.

Imoto H, Rauch N, Neve AJ, Khorsand F, Kreileder M, Alexopoulos LG, Rauch J, Okada M, Kholodenko BN, Rukhlenko OS. Imoto H, et al. Among authors: kholodenko bn. Biomolecules. 2023 Aug 2;13(8):1212. doi: 10.3390/biom13081212. Biomolecules. 2023. PMID: 37627277 Free PMC article.

2

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise.

Birtwistle MR, Rauch J, Kiyatkin A, Aksamitiene E, Dobrzyński M, Hoek JB, Kolch W, Ogunnaike BA, Kholodenko BN. Birtwistle MR, et al. Among authors: kholodenko bn. BMC Syst Biol. 2012 Aug 24;6:109. doi: 10.1186/1752-0509-6-109. BMC Syst Biol. 2012. PMID: 22920937 Free PMC article.

3

Evaluating strategies to normalise biological replicates of Western blot data.

Degasperi A, Birtwistle MR, Volinsky N, Rauch J, Kolch W, Kholodenko BN. Degasperi A, et al. Among authors: kholodenko bn. PLoS One. 2014 Jan 27;9(1):e87293. doi: 10.1371/journal.pone.0087293. eCollection 2014. PLoS One. 2014. PMID: 24475266 Free PMC article.

4

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation.

Jambrina PG, Rauch N, Pilkington R, Rybakova K, Nguyen LK, Kholodenko BN, Buchete NV, Kolch W, Rosta E. Jambrina PG, et al. Among authors: kholodenko bn. Angew Chem Int Ed Engl. 2016 Jan 18;55(3):983-6. doi: 10.1002/anie.201509272. Epub 2015 Dec 8. Angew Chem Int Ed Engl. 2016. PMID: 26644280 Free PMC article.

5

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.

Fey D, Halasz M, Dreidax D, Kennedy SP, Hastings JF, Rauch N, Munoz AG, Pilkington R, Fischer M, Westermann F, Kolch W, Kholodenko BN, Croucher DR. Fey D, et al. Among authors: kholodenko bn. Sci Signal. 2015 Dec 22;8(408):ra130. doi: 10.1126/scisignal.aab0990. Sci Signal. 2015. PMID: 26696630

6

The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells.

Fey D, Matallanas D, Rauch J, Rukhlenko OS, Kholodenko BN. Fey D, et al. Among authors: kholodenko bn. Semin Cell Dev Biol. 2016 Oct;58:96-107. doi: 10.1016/j.semcdb.2016.06.011. Epub 2016 Jun 24. Semin Cell Dev Biol. 2016. PMID: 27350026 Review.

7

MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance.

Rauch N, Rukhlenko OS, Kolch W, Kholodenko BN. Rauch N, et al. Among authors: kholodenko bn. Curr Opin Struct Biol. 2016 Dec;41:151-158. doi: 10.1016/j.sbi.2016.07.019. Epub 2016 Aug 10. Curr Opin Struct Biol. 2016. PMID: 27521656 Free article. Review.

8

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.

Erickson KE, Rukhlenko OS, Posner RG, Hlavacek WS, Kholodenko BN. Erickson KE, et al. Among authors: kholodenko bn. Semin Cancer Biol. 2019 Feb;54:162-173. doi: 10.1016/j.semcancer.2018.02.008. Epub 2018 Mar 5. Semin Cancer Biol. 2019. PMID: 29518522 Free PMC article. Review.

9

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling.

Rukhlenko OS, Khorsand F, Krstic A, Rozanc J, Alexopoulos LG, Rauch N, Erickson KE, Hlavacek WS, Posner RG, Gómez-Coca S, Rosta E, Fitzgibbon C, Matallanas D, Rauch J, Kolch W, Kholodenko BN. Rukhlenko OS, et al. Among authors: kholodenko bn. Cell Syst. 2018 Aug 22;7(2):161-179.e14. doi: 10.1016/j.cels.2018.06.002. Epub 2018 Jul 11. Cell Syst. 2018. PMID: 30007540 Free PMC article.

10

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction.

Thomaseth C, Fey D, Santra T, Rukhlenko OS, Radde NE, Kholodenko BN. Thomaseth C, et al. Among authors: kholodenko bn. Sci Rep. 2018 Nov 1;8(1):16217. doi: 10.1038/s41598-018-34353-3. Sci Rep. 2018. PMID: 30385767 Free PMC article.

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