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Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure.
Di Trani CA, Cirella A, Arrizabalaga L, Alvarez M, Bella Á, Fernandez-Sendin M, Russo-Cabrera JS, Gomar C, Ardaiz N, Teijeira A, Bolaños E, González-Gomariz J, Otano I, Aranda F, Palencia B, Segués A, Huang S, van Duijnhoven SMJ, van Elsas A, Melero I, Berraondo P. Di Trani CA, et al. Among authors: van elsas a. Mol Ther Nucleic Acids. 2023 Jul 19;33:599-616. doi: 10.1016/j.omtn.2023.07.020. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37637207 Free PMC article.
Integrated Single-Cell (Phospho-)Protein and RNA Detection Uncovers Phenotypic Characteristics and Active Signal Transduction of Human Antibody-Secreting Cells.
van Buijtenen E, Janssen W, Vink P, Habraken MJM, Wingens LJA, van Elsas A, Huck WTS, van Buggenum JAGL, van Eenennaam H. van Buijtenen E, et al. Among authors: van elsas a. Mol Cell Proteomics. 2023 Feb;22(2):100492. doi: 10.1016/j.mcpro.2023.100492. Epub 2023 Jan 7. Mol Cell Proteomics. 2023. PMID: 36623694 Free PMC article.
Cancer therapy with antibodies.
Paul S, Konig MF, Pardoll DM, Bettegowda C, Papadopoulos N, Wright KM, Gabelli SB, Ho M, van Elsas A, Zhou S. Paul S, et al. Among authors: van elsas a. Nat Rev Cancer. 2024 Jun;24(6):399-426. doi: 10.1038/s41568-024-00690-x. Epub 2024 May 13. Nat Rev Cancer. 2024. PMID: 38740967 Free PMC article. Review.
Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies.
Dang X, Guelen L, Lutje Hulsik D, Ermakov G, Hsieh EJ, Kreijtz J, Stammen-Vogelzangs J, Lodewijks I, Bertens A, Bramer A, Guadagnoli M, Nazabal A, van Elsas A, Fischmann T, Juan V, Beebe A, Beaumont M, van Eenennaam H. Dang X, et al. Among authors: van elsas a. MAbs. 2023 Jan-Dec;15(1):2285285. doi: 10.1080/19420862.2023.2285285. Epub 2023 Nov 27. MAbs. 2023. PMID: 38010385 Free PMC article.
Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy.
Guelen L, Fischmann TO, Wong J, Mauze S, Guadagnoli M, Bąbała N, Wagenaars J, Juan V, Rosen D, Prosise W, Habraken M, Lodewijks I, Gu D, Stammen-Vogelzangs J, Yu Y, Baker J, Lutje Hulsik D, Driessen-Engels L, Malashock D, Kreijtz J, Bertens A, de Vries E, Bovens A, Bramer A, Zhang Y, Wnek R, Troth S, Chartash E, Dobrenkov K, Sadekova S, van Elsas A, Cheung JK, Fayadat-Dilman L, Borst J, Beebe AM, Van Eenennaam H. Guelen L, et al. Among authors: van elsas a. J Immunother Cancer. 2022 Sep;10(9):e005049. doi: 10.1136/jitc-2022-005049. J Immunother Cancer. 2022. PMID: 36100308 Free PMC article.
Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors.
Rosin DL, Hall JP, Zheng S, Huang L, Campos-Bilderback S, Sandoval R, Bree A, Beaumont K, Miller E, Larsen J, Hariri G, Kaila N, Encarnacion IM, Gale JD, van Elsas A, Molitoris BA, Okusa MD. Rosin DL, et al. Among authors: van elsas a. Front Med (Lausanne). 2022 Jul 28;9:931293. doi: 10.3389/fmed.2022.931293. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35966871 Free PMC article.
Isotype selection for antibody-based cancer therapy.
Vukovic N, van Elsas A, Verbeek JS, Zaiss DMW. Vukovic N, et al. Among authors: van elsas a. Clin Exp Immunol. 2021 Mar;203(3):351-365. doi: 10.1111/cei.13545. Epub 2020 Nov 30. Clin Exp Immunol. 2021. PMID: 33155272 Free PMC article. Review.
51 results