Zlatev I - Search Results

1

Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.

Matsuda S, Bala S, Liao JY, Datta D, Mikami A, Woods L, Harp JM, Gilbert JA, Bisbe A, Manoharan RM, Kim M, Theile CS, Guenther DC, Jiang Y, Agarwal S, Maganti R, Schlegel MK, Zlatev I, Charisse K, Rajeev KG, Castoreno A, Maier M, Janas MM, Egli M, Chaput JC, Manoharan M. Matsuda S, et al. Among authors: zlatev i. J Am Chem Soc. 2023 Sep 13;145(36):19691-19706. doi: 10.1021/jacs.3c04744. Epub 2023 Aug 28. J Am Chem Soc. 2023. PMID: 37638886

2

Delta-di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase.

Zlatev I, Giraut A, Morvan F, Herdewijn P, Vasseur JJ. Zlatev I, et al. Bioorg Med Chem. 2009 Oct 1;17(19):7008-14. doi: 10.1016/j.bmc.2009.08.001. Epub 2009 Aug 8. Bioorg Med Chem. 2009. PMID: 19716707

3

Solid-phase chemical synthesis of 5'-triphosphate DNA, RNA, and chemically modified oligonucleotides.

Zlatev I, Manoharan M, Vasseur JJ, Morvan F. Zlatev I, et al. Curr Protoc Nucleic Acid Chem. 2012 Sep;Chapter 1:Unit1.28. doi: 10.1002/0471142700.nc0128s50. Curr Protoc Nucleic Acid Chem. 2012. PMID: 22956453

4

Automated parallel synthesis of 5'-triphosphate oligonucleotides and preparation of chemically modified 5'-triphosphate small interfering RNA.

Zlatev I, Lackey JG, Zhang L, Dell A, McRae K, Shaikh S, Duncan RG, Rajeev KG, Manoharan M. Zlatev I, et al. Bioorg Med Chem. 2013 Feb 1;21(3):722-32. doi: 10.1016/j.bmc.2012.11.043. Epub 2012 Dec 3. Bioorg Med Chem. 2013. PMID: 23260577

5

5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M. Zlatev I, et al. ACS Chem Biol. 2016 Apr 15;11(4):953-60. doi: 10.1021/acschembio.5b00654. Epub 2016 Jan 13. ACS Chem Biol. 2016. PMID: 26675211

6

Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.

Kel'in AV, Zlatev I, Harp J, Jayaraman M, Bisbe A, O'Shea J, Taneja N, Manoharan RM, Khan S, Charisse K, Maier MA, Egli M, Rajeev KG, Manoharan M. Kel'in AV, et al. Among authors: zlatev i. J Org Chem. 2016 Mar 18;81(6):2261-79. doi: 10.1021/acs.joc.5b02375. Epub 2016 Mar 4. J Org Chem. 2016. PMID: 26940174

7

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo.

Lee JB, Zhang K, Tam YY, Quick J, Tam YK, Lin PJ, Chen S, Liu Y, Nair JK, Zlatev I, Rajeev KG, Manoharan M, Rennie PS, Cullis PR. Lee JB, et al. Among authors: zlatev i. Mol Ther Nucleic Acids. 2016;5(8):e348. doi: 10.1038/mtna.2016.43. Mol Ther Nucleic Acids. 2016. PMID: 28131285 Free PMC article.

8

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.

Schlegel MK, Foster DJ, Kel'in AV, Zlatev I, Bisbe A, Jayaraman M, Lackey JG, Rajeev KG, Charissé K, Harp J, Pallan PS, Maier MA, Egli M, Manoharan M. Schlegel MK, et al. Among authors: zlatev i. J Am Chem Soc. 2017 Jun 28;139(25):8537-8546. doi: 10.1021/jacs.7b02694. Epub 2017 Jun 19. J Am Chem Soc. 2017. PMID: 28570818

9

Crystal structure of Middle East respiratory syndrome coronavirus helicase.

Hao W, Wojdyla JA, Zhao R, Han R, Das R, Zlatev I, Manoharan M, Wang M, Cui S. Hao W, et al. Among authors: zlatev i. PLoS Pathog. 2017 Jun 26;13(6):e1006474. doi: 10.1371/journal.ppat.1006474. eCollection 2017 Jun. PLoS Pathog. 2017. PMID: 28651017 Free PMC article.

10

4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.

Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ. Malek-Adamian E, et al. Among authors: zlatev i. J Am Chem Soc. 2017 Oct 18;139(41):14542-14555. doi: 10.1021/jacs.7b07582. Epub 2017 Oct 6. J Am Chem Soc. 2017. PMID: 28937776

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