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Page 1
Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.
Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. Nadel CM, et al. Among authors: gestwicki je. bioRxiv [Preprint]. 2023 Aug 16:2023.08.16.553575. doi: 10.1101/2023.08.16.553575. bioRxiv. 2023. Update in: Nat Commun. 2024 Sep 12;15(1):7972. doi: 10.1038/s41467-024-52075-1 PMID: 37645969 Free PMC article. Updated. Preprint.
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2.
Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko D, Moroz Y, Irwin JJ, Renslo AR, Taylor JC, Gestwicki JE, von Delft F, Ashworth A, Ahel I, Shoichet BK, Fraser JS. Gahbauer S, et al. Among authors: gestwicki je. bioRxiv [Preprint]. 2022 Jul 28:2022.06.27.497816. doi: 10.1101/2022.06.27.497816. bioRxiv. 2022. Update in: Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2212931120. doi: 10.1073/pnas.2212931120 PMID: 35794891 Free PMC article. Updated. Preprint.
Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry.
Wu T, Yu JC, Suresh A, Gale-Day ZJ, Alteen MG, Woo AS, Millbern Z, Johnson OT, Carroll EC, Partch CL, Fourches D, Vinueza NR, Vocadlo DJ, Gestwicki JE. Wu T, et al. Among authors: gestwicki je. bioRxiv [Preprint]. 2023 Jan 28:2023.01.23.525251. doi: 10.1101/2023.01.23.525251. bioRxiv. 2023. Update in: Nat Biotechnol. 2024 May 14. doi: 10.1038/s41587-024-02158-7 PMID: 36747624 Free PMC article. Updated. Preprint.
A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway.
Elsasser S, Elia LP, Morimoto RI, Powers ET, Finley D, Costa B, Budron M, Tokuno Z, Wang S, Iyer RG, Barth B, Mockler E, Finkbeiner S, Gestwicki JE, Richardson RAK, Stoeger T, Tan EP, Xiao Q, Cole CM, Massey LA, Garza D, Kelly JW, Rainbolt TK, Chou CC, Masto VB, Frydman J, Nixon RA. Elsasser S, et al. Among authors: gestwicki je. bioRxiv [Preprint]. 2023 Mar 24:2023.03.22.533675. doi: 10.1101/2023.03.22.533675. bioRxiv. 2023. PMID: 36993380 Free PMC article. Preprint.
De novo designed Hsp70 activator dissolves intracellular condensates.
Zhang JZ, Greenwood N, Hernandez J, Cuperus JT, Huang B, Ryder BD, Queitsch C, Gestwicki JE, Baker D. Zhang JZ, et al. Among authors: gestwicki je. bioRxiv [Preprint]. 2023 Sep 19:2023.09.18.558356. doi: 10.1101/2023.09.18.558356. bioRxiv. 2023. PMID: 37781598 Free PMC article. Preprint.
A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats.
Tanaka M, Fujikawa R, Sekiguchi T, Hernandez J, Johnson OT, Tanaka D, Kumafuji K, Serikawa T, Hoang Trung H, Hattori K, Mashimo T, Kuwamura M, Gestwicki JE, Kuramoto T. Tanaka M, et al. Among authors: gestwicki je. Front Neurosci. 2024 Feb 6;18:1263724. doi: 10.3389/fnins.2024.1263724. eCollection 2024. Front Neurosci. 2024. PMID: 38384479 Free PMC article.
Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors.
Lang BJ, Holton KM, Guerrero-Gimenez ME, Okusha Y, Magahis PT, Shi A, Neguse M, Venkatesh S, Nhu AM, Gestwicki JE, Calderwood SK. Lang BJ, et al. Among authors: gestwicki je. Cell Stress Chaperones. 2024 Jun;29(3):456-471. doi: 10.1016/j.cstres.2024.04.006. Epub 2024 May 3. Cell Stress Chaperones. 2024. PMID: 38703814 Free PMC article.
Stress biology: Complexity and multifariousness in health and disease.
Mayer MP, Blair L, Blatch GL, Borges TJ, Chadli A, Chiosis G, de Thonel A, Dinkova-Kostova A, Ecroyd H, Edkins AL, Eguchi T, Fleshner M, Foley KP, Fragkostefanakis S, Gestwicki J, Goloubinoff P, Heritz JA, Heske CM, Hibshman JD, Joutsen J, Li W, Lynes M, Mendillo ML, Mivechi N, Mokoena F, Okusha Y, Prahlad V, Repasky E, Sannino S, Scalia F, Shalgi R, Sistonen L, Sontag E, van Oosten-Hawle P, Vihervaara A, Wickramaratne A, Wang SXY, Zininga T. Mayer MP, et al. Cell Stress Chaperones. 2024 Feb;29(1):143-157. doi: 10.1016/j.cstres.2024.01.006. Epub 2024 Feb 3. Cell Stress Chaperones. 2024. PMID: 38311120 Free PMC article.
J-domain proteins: From molecular mechanisms to diseases.
Marszalek J, De Los Rios P, Cyr D, Mayer MP, Adupa V, Andréasson C, Blatch GL, Braun JEA, Brodsky JL, Bukau B, Chapple JP, Conz C, Dementin S, Genevaux P, Genest O, Goloubinoff P, Gestwicki J, Hammond CM, Hines JK, Ishikawa K, Joachimiak LA, Kirstein J, Liberek K, Mokranjac D, Nillegoda N, Ramos CHI, Rebeaud M, Ron D, Rospert S, Sahi C, Shalgi R, Tomiczek B, Ushioda R, Ustyantseva E, Ye Y, Zylicz M, Kampinga HH. Marszalek J, et al. Cell Stress Chaperones. 2024 Feb;29(1):21-33. doi: 10.1016/j.cstres.2023.12.002. Epub 2023 Dec 23. Cell Stress Chaperones. 2024. PMID: 38320449 Free PMC article.
238 results