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Synthesis and biological evaluation of xanthine derivatives with phenacyl group as tryptophan hydroxylase 1 (TPH1) inhibitors for obesity and fatty liver disease.
Yoon J, Choi WI, Parameswaran S, Lee GB, Choi BW, Kim P, Shin DS, Jeong HN, Lee SM, Oh CJ, Jeon JH, Lee IK, Bae MA, Kim H, Ahn JH. Yoon J, et al. Among authors: lee gb, lee sm, lee ik. Bioorg Med Chem Lett. 2023 Oct 1;94:129461. doi: 10.1016/j.bmcl.2023.129461. Epub 2023 Aug 29. Bioorg Med Chem Lett. 2023. PMID: 37652099
Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases.
Lee D, Pagire HS, Pagire SH, Bae EJ, Dighe M, Kim M, Lee KM, Jang YK, Jaladi AK, Jung KY, Yoo EK, Gim HE, Lee S, Choi WI, Chi YI, Song JS, Bae MA, Jeon YH, Lee GH, Liu KH, Lee T, Park S, Jeon JH, Lee IK, Ahn JH. Lee D, et al. J Med Chem. 2019 Jan 24;62(2):575-588. doi: 10.1021/acs.jmedchem.8b01168. Epub 2019 Jan 9. J Med Chem. 2019. PMID: 30623649
Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease.
Kim M, Hwang I, Pagire HS, Pagire SH, Choi W, Choi WG, Yoon J, Lee WM, Song JS, Yoo EK, Lee SM, Kim MJ, Bae MA, Kim D, Lee H, Lee EY, Jeon JH, Lee IK, Kim H, Ahn JH. Kim M, et al. Among authors: lee ey, lee wm, lee h, lee sm, lee ik. J Med Chem. 2020 Apr 23;63(8):4171-4182. doi: 10.1021/acs.jmedchem.0c00002. Epub 2020 Apr 14. J Med Chem. 2020. PMID: 32285676
Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor γ (ERRγ) Inverse Agonists.
Kim J, Woo SY, Im CY, Yoo EK, Lee S, Kim HJ, Hwang HJ, Cho JH, Lee WS, Yoon H, Kim S, Kwon OB, Hwang H, Kim KH, Jeon JH, Singh TD, Kim SW, Hwang SY, Choi HS, Lee IK, Kim SH, Jeon YH, Chin J, Cho SJ. Kim J, et al. J Med Chem. 2016 Nov 23;59(22):10209-10227. doi: 10.1021/acs.jmedchem.6b01204. Epub 2016 Nov 9. J Med Chem. 2016. PMID: 27805390
An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Kim J, Hwang H, Yoon H, Lee JE, Oh JM, An H, Ji HD, Lee S, Cha E, Ma MJ, Kim DS, Lee SJ, Kadayat TM, Song J, Lee SW, Jeon JH, Park KG, Lee IK, Jeon YH, Chin J, Cho SJ. Kim J, et al. Eur J Med Chem. 2020 Nov 1;205:112501. doi: 10.1016/j.ejmech.2020.112501. Epub 2020 Jul 14. Eur J Med Chem. 2020. PMID: 32758860
Correction to Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases.
Lee D, Pagire HS, Pagire SH, Bae EJ, Dighe M, Kim M, Lee KM, Jang YK, Jaladi AK, Jung KY, Yoo EK, Gim HE, Lee S, Choi WI, Chi YI, Song JS, Bae MA, Jeon YH, Lee GH, Liu KH, Lee T, Park S, Jeon JH, Lee IK, Ahn JH. Lee D, et al. J Med Chem. 2019 Mar 14;62(5):2849. doi: 10.1021/acs.jmedchem.9b00249. Epub 2019 Feb 27. J Med Chem. 2019. PMID: 30811938 No abstract available.
Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
Kim J, Song J, Ji HD, Yoo EK, Lee JE, Lee SB, Oh JM, Lee S, Hwang JS, Yoon H, Kim DS, Lee SJ, Jeong M, Lee S, Kim KH, Choi HS, Lee SW, Park KG, Lee IK, Kim SH, Hwang H, Jeon YH, Chin J, Cho SJ. Kim J, et al. J Med Chem. 2019 Feb 28;62(4):1837-1858. doi: 10.1021/acs.jmedchem.8b01296. Epub 2019 Feb 4. J Med Chem. 2019. PMID: 30657313
6,080 results