Paccaly A - Search Results

1

Immunogenicity of Cemiplimab: Low Incidence of Antidrug Antibodies and Cut-Point Suitability Across Tumor Types.

Valentine JL, Dengler A, Zhao A, Truong T, McAfee S, Hassanein M, Irvin SC, Chen J, Meng X, Yan H, Torri A, Sumner G, Andisik MD, Paccaly A, Partridge MA. Valentine JL, et al. Among authors: paccaly a. J Clin Pharmacol. 2024 Jan;64(1):125-136. doi: 10.1002/jcph.2340. Epub 2023 Sep 20. J Clin Pharmacol. 2024. PMID: 37656820

2

Utilizing physiologically based pharmacokinetic modeling to inform formulation and clinical development for a compound with pH-dependent solubility.

Chung J, Alvarez-Nunez F, Chow V, Daurio D, Davis J, Dodds M, Emery M, Litwiler K, Paccaly A, Peng J, Rock B, Wienkers L, Yang C, Yu Z, Wahlstrom J. Chung J, et al. Among authors: paccaly a. J Pharm Sci. 2015 Apr;104(4):1522-32. doi: 10.1002/jps.24339. Epub 2015 Jan 15. J Pharm Sci. 2015. PMID: 25641187

3

Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients.

Diacon AH, Dawson R, Hanekom M, Narunsky K, Venter A, Hittel N, Geiter LJ, Wells CD, Paccaly AJ, Donald PR. Diacon AH, et al. Among authors: paccaly aj. Int J Tuberc Lung Dis. 2011 Jul;15(7):949-54. doi: 10.5588/ijtld.10.0616. Int J Tuberc Lung Dis. 2011. PMID: 21682970 Clinical Trial.

4

Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, and acetylsalicylic acid.

Hinder M, Frick A, Rosenburg R, Hesse G, Ozoux ML, Laux V, Scholtz H, Gebauer A, Paccaly A. Hinder M, et al. Among authors: paccaly a. Thromb Haemost. 2006 Feb;95(2):224-8. doi: 10.1160/TH05-08-0592. Thromb Haemost. 2006. PMID: 16493482 Clinical Trial.

5

Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, with tirofiban in healthy volunteers.

Hinder M, Paccaly A, Frick A, Shukla U, Simcox K, Miller B, Gebauer A. Hinder M, et al. Among authors: paccaly a. Thromb Haemost. 2005 Apr;93(4):794-5. Thromb Haemost. 2005. PMID: 15841331 Clinical Trial. No abstract available.

6

Pharmacodynamic markers in the early clinical assessment of otamixaban, a direct factor Xa inhibitor.

Paccaly A, Ozoux ML, Chu V, Simcox K, Marks V, Freyburger G, Sibille M, Shukla U. Paccaly A, et al. Thromb Haemost. 2005 Dec;94(6):1156-63. doi: 10.1160/TH05-05-0347. Thromb Haemost. 2005. PMID: 16411387 Clinical Trial.

7

Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma.

Boot JD, de Haas S, Tarasevych S, Roy C, Wang L, Amin D, Cohen J, Sterk PJ, Miller B, Paccaly A, Burggraaf J, Cohen AF, Diamant Z. Boot JD, et al. Among authors: paccaly a. Am J Respir Crit Care Med. 2007 Mar 1;175(5):450-7. doi: 10.1164/rccm.200608-1186OC. Epub 2006 Dec 14. Am J Respir Crit Care Med. 2007. PMID: 17170385 Clinical Trial.

8

Immunogenicity of Sarilumab Monotherapy in Patients with Rheumatoid Arthritis Who Were Inadequate Responders or Intolerant to Disease-Modifying Antirheumatic Drugs.

Wells AF, Parrino J, Mangan EK, Paccaly A, Lin Y, Xu C, Fan C, Graham NMH, van Hoogstraten H, Torri A. Wells AF, et al. Among authors: paccaly a. Rheumatol Ther. 2019 Sep;6(3):339-352. doi: 10.1007/s40744-019-0157-3. Epub 2019 May 14. Rheumatol Ther. 2019. PMID: 31090044 Free PMC article.

9

Pharmacokinetics and Pharmacodynamics of Subcutaneous Sarilumab and Intravenous Tocilizumab Following Single-Dose Administration in Patients With Active Rheumatoid Arthritis on Stable Methotrexate.

Paccaly AJ, Kovalenko P, Parrino J, Boyapati A, Xu C, van Hoogstraten H, Ishii T, Davis JD, DiCioccio AT. Paccaly AJ, et al. J Clin Pharmacol. 2021 Jan;61(1):90-104. doi: 10.1002/jcph.1703. Epub 2020 Jul 29. J Clin Pharmacol. 2021. PMID: 32726514 Free PMC article. Clinical Trial.

10

Dose exploration results from Phase 1 study of cemiplimab, a human monoclonal programmed death (PD)-1 antibody, in Japanese patients with advanced malignancies.

Kitano S, Shimizu T, Koyama T, Ebata T, Iwasa S, Kondo S, Shimomura A, Fujiwara Y, Yamamoto N, Paccaly A, Li S, Rietschel P, Sims T. Kitano S, et al. Among authors: paccaly a. Cancer Chemother Pharmacol. 2021 Jan;87(1):53-64. doi: 10.1007/s00280-020-04161-6. Epub 2020 Nov 4. Cancer Chemother Pharmacol. 2021. PMID: 33146741 Free PMC article. Clinical Trial.

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