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Page 1
Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats.
Hsueh HT, Chou RT, Rai U, Kolodziejski P, Liyanage W, Pejavar J, Mozzer A, Davison C, Appell MB, Kim YC, Leo KT, Kwon H, Sista M, Anders NM, Hemingway A, Rompicharla SVK, Pitha I, Zack DJ, Hanes J, Cummings MP, Ensign LM. Hsueh HT, et al. Among authors: appell mb. J Control Release. 2023 Oct;362:371-380. doi: 10.1016/j.jconrel.2023.08.058. Epub 2023 Sep 4. J Control Release. 2023. PMID: 37657693 Free PMC article.
A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells.
Kim YC, Hsueh HT, Shin MD, Berlinicke CA, Han H, Anders NM, Hemingway A, Leo KT, Chou RT, Kwon H, Appell MB, Rai U, Kolodziejski P, Eberhart C, Pitha I, Zack DJ, Hanes J, Ensign LM. Kim YC, et al. Among authors: appell mb. Drug Deliv Transl Res. 2022 Apr;12(4):826-837. doi: 10.1007/s13346-021-00987-6. Epub 2021 Apr 26. Drug Deliv Transl Res. 2022. PMID: 33900546 Free PMC article.
Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells.
Hsueh HT, Kim YC, Pitha I, Shin MD, Berlinicke CA, Chou RT, Kimball E, Schaub J, Quillen S, Leo KT, Han H, Xiao A, Kim Y, Appell M, Rai U, Kwon H, Kolodziejski P, Ogunnaike L, Anders NM, Hemingway A, Jefferys JL, Date AA, Eberhart C, Johnson TV, Quigley HA, Zack DJ, Hanes J, Ensign LM. Hsueh HT, et al. Pharmaceutics. 2021 May 1;13(5):647. doi: 10.3390/pharmaceutics13050647. Pharmaceutics. 2021. PMID: 34062883 Free PMC article.
Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery.
Hsueh HT, Chou RT, Rai U, Liyanage W, Kim YC, Appell MB, Pejavar J, Leo KT, Davison C, Kolodziejski P, Mozzer A, Kwon H, Sista M, Anders NM, Hemingway A, Rompicharla SVK, Edwards M, Pitha I, Hanes J, Cummings MP, Ensign LM. Hsueh HT, et al. Among authors: appell mb. Nat Commun. 2023 May 2;14(1):2509. doi: 10.1038/s41467-023-38056-w. Nat Commun. 2023. PMID: 37130851 Free PMC article.
Next generation therapeutics for retinal neurodegenerative diseases.
Appell MB, Pejavar J, Pasupathy A, Rompicharla SVK, Abbasi S, Malmberg K, Kolodziejski P, Ensign LM. Appell MB, et al. J Control Release. 2024 Mar;367:708-736. doi: 10.1016/j.jconrel.2024.01.063. Epub 2024 Feb 10. J Control Release. 2024. PMID: 38295996 Review.
Hypotonic, gel-forming delivery system for vaginal drug administration.
Shapiro RL, Bockley KM, Hsueh HT, Appell MB, Carter DM, Ortiz J, Brayton C, Ensign LM. Shapiro RL, et al. Among authors: appell mb. J Control Release. 2024 Jul;371:101-110. doi: 10.1016/j.jconrel.2024.05.037. Epub 2024 May 24. J Control Release. 2024. PMID: 38782065