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Page 1
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG, Chen S, Todorov PV, Sharapov S, David A, Marullo L, Mägi R, Rujan RM, Ahlqvist E, Thorleifsson G, Gao Η, Εvangelou Ε, Benyamin B, Scott RA, Isaacs A, Zhao JH, Willems SM, Johnson T, Gieger C, Grallert H, Meisinger C, Müller-Nurasyid M, Strawbridge RJ, Goel A, Rybin D, Albrecht E, Jackson AU, Stringham HM, Corrêa IR Jr, Farber-Eger E, Steinthorsdottir V, Uitterlinden AG, Munroe PB, Brown MJ, Schmidberger J, Holmen O, Thorand B, Hveem K, Wilsgaard T, Mohlke KL, Wang Z; GWA-PA Consortium; Shmeliov A, den Hoed M, Loos RJF, Kratzer W, Haenle M, Koenig W, Boehm BO, Tan TM, Tomas A, Salem V, Barroso I, Tuomilehto J, Boehnke M, Florez JC, Hamsten A, Watkins H, Njølstad I, Wichmann HE, Caulfield MJ, Khaw KT, van Duijn CM, Hofman A, Wareham NJ, Langenberg C, Whitfield JB, Martin NG, Montgomery G, Scapoli C, Tzoulaki I, Elliott P, Thorsteinsdottir U, Stefansson K, Brittain EL, McCarthy MI, Froguel P, Sexton PM, Wootten D, Groop L, Dupuis J, Meigs JB, Deganutti G, Demirkan A, Pers TH, Reynolds CA, Aulchenko YS, Kaakinen MA, Jones B, Prokopenko I; Meta-Analysis of Glucose and Insulin-Related Traits … See abstract for full author list ➔ Lagou V, et al. Among authors: rujan rm. Nat Genet. 2023 Sep;55(9):1448-1461. doi: 10.1038/s41588-023-01462-3. Epub 2023 Sep 7. Nat Genet. 2023. PMID: 37679419 Free PMC article.
Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors.
Deganutti G, Atanasio S, Rujan RM, Sexton PM, Wootten D, Reynolds CA. Deganutti G, et al. Among authors: rujan rm. Front Mol Biosci. 2021 Aug 26;8:720561. doi: 10.3389/fmolb.2021.720561. eCollection 2021. Front Mol Biosci. 2021. PMID: 34513925 Free PMC article.
Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors.
Hendrikse ER, Liew LP, Bower RL, Bonnet M, Jamaluddin MA, Prodan N, Richards KD, Walker CS, Pairaudeau G, Smith DM, Rujan RM, Sudra R, Reynolds CA, Booe JM, Pioszak AA, Flanagan JU, Hay MP, Hay DL. Hendrikse ER, et al. Among authors: rujan rm. ACS Pharmacol Transl Sci. 2020 Mar 12;3(2):305-320. doi: 10.1021/acsptsci.9b00108. eCollection 2020 Apr 10. ACS Pharmacol Transl Sci. 2020. PMID: 32296770 Free PMC article.
In vivo functional profiling and structural characterisation of the human Glp1r A316T variant.
El Eid L, Deane-Alder K, Rujan RM, Mariam Z, Oqua AI, Manchanda Y, Belousoff MJ, Bernardino de la Serna J, Sloop KW, Rutter GA, Montoya A, Withers DJ, Millership SJ, Bouzakri K, Jones B, Reynolds CA, Sexton PM, Wootten D, Deganutti G, Tomas A. El Eid L, et al. Among authors: rujan rm. bioRxiv [Preprint]. 2024 Nov 10:2024.10.19.619191. doi: 10.1101/2024.10.19.619191. bioRxiv. 2024. PMID: 39484598 Free PMC article. Preprint.