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Abnormal vascular structure and function within brain metastases is linked to pembrolizumab resistance.
Kim AE, Lou KW, Giobbie-Hurder A, Chang K, Gidwani M, Hoebel K, Patel JB, Cleveland MC, Singh P, Bridge CP, Ahmed SR, Bearce BA, Liu W, Fuster-Garcia E, Lee EQ, Lin NU, Overmoyer B, Wen PY, Nayak L, Cohen JV, Dietrich J, Eichler A, Heist R, Krop I, Lawrence D, Ligibel J, Tolaney S, Mayer E, Winer E, Perrino CM, Summers EJ, Mahar M, Oh K, Shih HA, Cahill DP, Rosen BR, Yen YF, Kalpathy-Cramer J, Martinez-Lage M, Sullivan RJ, Brastianos PK, Emblem KE, Gerstner ER. Kim AE, et al. Among authors: lou kw. Neuro Oncol. 2024 May 3;26(5):965-974. doi: 10.1093/neuonc/noad236. Neuro Oncol. 2024. PMID: 38070147 Clinical Trial.
Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy.
Kim AE, Lou KW, Giobbie-Hurder A, Chang K, Gidwani M, Hoebel K, Patel JB, Cleveland MC, Singh P, Bridge CP, Ahmed SR, Bearce BA, Liu W, Fuster-Garcia E, Lee EQ, Lin NU, Overmoyer B, Wen PY, Nayak L, Cohen JV, Dietrich J, Eichler A, Heist R, Krop I, Lawrence D, Ligibel J, Tolaney S, Mayer E, Winer E, Perrino CM, Summers EJ, Mahar M, Oh K, Shih HA, Cahill DP, Rosen BR, Yen YF, Kalpathy-Cramer J, Martinez-Lage M, Sullivan RJ, Brastianos PK, Emblem KE, Gerstner ER. Kim AE, et al. Among authors: lou kw. bioRxiv [Preprint]. 2023 Aug 28:2023.08.25.554868. doi: 10.1101/2023.08.25.554868. bioRxiv. 2023. PMID: 37693537 Free PMC article. Preprint.
Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas.
Brastianos PK, Kim AE, Giobbie-Hurder A, Lee EQ, Wang N, Eichler AF, Chukwueke U, Forst DA, Arrillaga-Romany IC, Dietrich J, Corbin Z, Moliterno J, Baehring J, White M, Lou KW, Larson J, de Sauvage MA, Evancic K, Mora J, Nayyar N, Loeffler J, Oh K, Shih HA, Curry WT, Cahill DP, Barker FG, Gerstner ER, Santagata S. Brastianos PK, et al. Among authors: lou kw. Nat Commun. 2022 Mar 14;13(1):1325. doi: 10.1038/s41467-022-29052-7. Nat Commun. 2022. PMID: 35289329 Free PMC article. Clinical Trial.