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Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study.
Prasch H, Wolfsgruber A, Thonhofer M, Culum A, Mandl C, Weber P, Zündel M, Nasseri SA, Gonzalez Santana A, Tegl G, Nidetzky B, Gruber K, Stütz AE, Withers SG, Wrodnigg TM. Prasch H, et al. Among authors: stutz ae. Chembiochem. 2023 Dec 1;24(23):e202300480. doi: 10.1002/cbic.202300480. Epub 2023 Oct 10. Chembiochem. 2023. PMID: 37715738
Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors.
Wrodnigg TM, Diness F, Gruber C, Häusler H, Lundt I, Rupitz K, Steiner AJ, Stütz AE, Tarling CA, Withers SG, Wölfler H. Wrodnigg TM, et al. Among authors: stutz ae. Bioorg Med Chem. 2004 Jul 1;12(13):3485-95. doi: 10.1016/j.bmc.2004.04.037. Bioorg Med Chem. 2004. PMID: 15186833
Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols.
Greimel P, Häusler H, Lundt I, Rupitz K, Stütz AE, Tarling CA, Withers SG, Wrodnigg TM. Greimel P, et al. Among authors: stutz ae. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2067-70. doi: 10.1016/j.bmcl.2006.01.095. Epub 2006 Feb 14. Bioorg Med Chem Lett. 2006. PMID: 16481162
58 results