Yang LL - Search Results

1

Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.

Yan YH, Zhang TT, Li R, Wang SY, Wei LL, Wang XY, Zhu KR, Li SR, Liang GQ, Yang ZB, Yang LL, Qin S, Li GB. Yan YH, et al. Among authors: yang zb, yang ll. J Med Chem. 2023 Oct 12;66(19):13746-13767. doi: 10.1021/acs.jmedchem.3c01189. Epub 2023 Oct 4. J Med Chem. 2023. PMID: 37791640

2

Discovery of novel mGluR1 antagonists: a multistep virtual screening approach based on an SVM model and a pharmacophore hypothesis significantly increases the hit rate and enrichment factor.

Li GB, Yang LL, Feng S, Zhou JP, Huang Q, Xie HZ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1736-40. doi: 10.1016/j.bmcl.2011.01.087. Epub 2011 Jan 25. Bioorg Med Chem Lett. 2011. PMID: 21316965

3

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

Yang LL, Li GB, Yan HX, Sun QZ, Ma S, Ji P, Wang ZR, Feng S, Zou J, Yang SY. Yang LL, et al. Among authors: yang sy. Eur J Med Chem. 2012 Oct;56:30-8. doi: 10.1016/j.ejmech.2012.08.007. Epub 2012 Aug 14. Eur J Med Chem. 2012. PMID: 22944772

4

Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.

Yang LL, Li GB, Ma S, Zou C, Zhou S, Sun QZ, Cheng C, Chen X, Wang LJ, Feng S, Li LL, Yang SY. Yang LL, et al. Among authors: yang sy. J Med Chem. 2013 Feb 28;56(4):1641-55. doi: 10.1021/jm301537p. Epub 2013 Feb 19. J Med Chem. 2013. PMID: 23362959

5

ID-Score: a new empirical scoring function based on a comprehensive set of descriptors related to protein-ligand interactions.

Li GB, Yang LL, Wang WJ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. J Chem Inf Model. 2013 Mar 25;53(3):592-600. doi: 10.1021/ci300493w. Epub 2013 Feb 26. J Chem Inf Model. 2013. PMID: 23394072

6

SC-535, a novel oral multikinase inhibitor, showed potent antitumor activity in human melanoma models.

Chen X, Ji P, Yang HW, Yang LL, Zhou S, Zhong L, Ma S, Fu XY, Zhou C, Li GB, Zheng MW, Wei YQ, Yang SY. Chen X, et al. Among authors: yang sy, yang ll, yang hw. Cell Physiol Biochem. 2013;32(1):138-53. doi: 10.1159/000350123. Epub 2013 Jul 12. Cell Physiol Biochem. 2013. PMID: 23867251 Free article.

7

A combined molecular docking-based and pharmacophore-based target prediction strategy with a probabilistic fusion method for target ranking.

Li GB, Yang LL, Xu Y, Wang WJ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. J Mol Graph Model. 2013 Jul;44:278-85. doi: 10.1016/j.jmgm.2013.07.005. Epub 2013 Jul 23. J Mol Graph Model. 2013. PMID: 23933279

8

Virtual screening in small molecule discovery for epigenetic targets.

Li GB, Yang LL, Yuan Y, Zou J, Cao Y, Yang SY, Xiang R, Xiang M. Li GB, et al. Among authors: yang sy, yang ll. Methods. 2015 Jan;71:158-66. doi: 10.1016/j.ymeth.2014.11.010. Epub 2014 Nov 21. Methods. 2015. PMID: 25462557

9

LEADOPT: an automatic tool for structure-based lead optimization, and its application in structural optimizations of VEGFR2 and SYK inhibitors.

Li GB, Ji S, Yang LL, Zhang RJ, Chen K, Zhong L, Ma S, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. Eur J Med Chem. 2015 Mar 26;93:523-38. doi: 10.1016/j.ejmech.2015.02.019. Epub 2015 Feb 14. Eur J Med Chem. 2015. PMID: 25743214

10

An integrated molecular docking and rescoring method for predicting the sensitivity spectrum of various serine hydrolases to organophosphorus pesticides.

Yang LL, Yang X, Li GB, Fan KG, Yin PF, Chen XG. Yang LL, et al. Among authors: yang x. J Sci Food Agric. 2016 Apr;96(6):2184-92. doi: 10.1002/jsfa.7335. Epub 2015 Aug 3. J Sci Food Agric. 2016. PMID: 26172068

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