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Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.

Morales-Maldonado A, Humphry M, Figg N, Clarke MC. Morales-Maldonado A, et al. Atherosclerosis. 2024 Mar;390:117308. doi: 10.1016/j.atherosclerosis.2023.117308. Epub 2023 Sep 28. Atherosclerosis. 2024. PMID: 37821269 Free article.

Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production.

Burzynski LC, Morales-Maldonado A, Rodgers A, Kitt LA, Humphry M, Figg N, Bennett MR, Clarke MCH. Burzynski LC, et al. Among authors: morales maldonado a. Cardiovasc Res. 2023 Oct 16;119(12):2179-2189. doi: 10.1093/cvr/cvad091. Cardiovasc Res. 2023. PMID: 37309666 Free PMC article.

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