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Single Amino Acid Mutation Decouples Photochemistry of the BLUF Domain from the Enzymatic Function of OaPAC and Drives the Enzyme to a Switched-on State.
Tolentino Collado J, Bodis E, Pasitka J, Szucs M, Fekete Z, Kis-Bicskei N, Telek E, Pozsonyi K, Kapetanaki SM, Greetham G, Tonge PJ, Meech SR, Lukacs A. Tolentino Collado J, et al. Among authors: tonge pj. J Mol Biol. 2024 Mar 1;436(5):168312. doi: 10.1016/j.jmb.2023.168312. Epub 2023 Oct 10. J Mol Biol. 2024. PMID: 37827329 Free article.
[No title available]
[No authors listed] [No authors listed] PMID: 36783605
Preclinical Positron Emission Tomography (PET) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[18F]F-p-Aminobenzoic Acid ([18F]F-PABA).
Pollard-Kerning AC, Li K, Li Y, Ahn SH, Wang M, Akoglu M, Bravo E, DelloRusso F, Akula HK, Qu W, Meimetis L, Schlyer DJ, Komatsu DE, Tonge PJ. Pollard-Kerning AC, et al. Among authors: tonge pj. ACS Infect Dis. 2024 Nov 8;10(11):3765-3774. doi: 10.1021/acsinfecdis.4c00075. Epub 2024 Oct 21. ACS Infect Dis. 2024. PMID: 39432749
Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor YtvA: From Photoactivation to Downstream Regulation.
He Y, Collado JT, Iuliano JN, Woroniecka HA, Hall CR, Gil AA, Laptenok SP, Greetham GM, Illarionov B, Bacher A, Fischer M, French JB, Lukacs A, Meech SR, Tonge PJ. He Y, et al. Among authors: tonge pj. ACS Chem Biol. 2024 Mar 15;19(3):696-706. doi: 10.1021/acschembio.3c00722. Epub 2024 Feb 22. ACS Chem Biol. 2024. PMID: 38385342 Free PMC article.
Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi YM, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun YA, Rizzo RC, Haley JD. Coant N, et al. Among authors: tonge pj. Bioorg Chem. 2023 Oct;139:106747. doi: 10.1016/j.bioorg.2023.106747. Epub 2023 Jul 27. Bioorg Chem. 2023. PMID: 37531819 Free PMC article.
182 results