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Effects of metabolic cancer therapy on tumor microenvironment.
Hyroššová P, Milošević M, Škoda J, Vachtenheim J Jr, Rohlena J, Rohlenová K. Hyroššová P, et al. Among authors: rohlena j. Front Oncol. 2022 Dec 13;12:1046630. doi: 10.3389/fonc.2022.1046630. eCollection 2022. Front Oncol. 2022. PMID: 36582801 Free PMC article. Review.
Mitochondrial HER2 stimulates respiration and promotes tumorigenicity.
Novotna E, Milosevic M, Prukova D, Magalhaes-Novais S, Dvorakova S, Dmytruk K, Gemperle J, Zudova D, Nickl T, Vrbacky M, Rosel D, Filimonenko V, Prochazka J, Brabek J, Neuzil J, Rohlenova K, Rohlena J. Novotna E, et al. Among authors: rohlena j. Eur J Clin Invest. 2024 Jun;54(6):e14174. doi: 10.1111/eci.14174. Epub 2024 Jan 30. Eur J Clin Invest. 2024. PMID: 38291340
Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners.
Sharma P, Maklashina E, Voehler M, Balintova S, Dvorakova S, Kraus M, Hadrava Vanova K, Nahacka Z, Zobalova R, Boukalova S, Cunatova K, Mracek T, Ghayee HK, Pacak K, Rohlena J, Neuzil J, Cecchini G, Iverson TM. Sharma P, et al. Among authors: rohlena j. Nat Commun. 2024 Jan 11;15(1):473. doi: 10.1038/s41467-023-44563-7. Nat Commun. 2024. PMID: 38212624 Free PMC article.
MitoTam-01 Trial: Mitochondrial Targeting as Plausible Approach to Cancer Therapy. Comment on Yap et al. Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials. Nat. Med. 2023, 29, 115-126.
Neuzil J, Rohlena J, Werner L, Bielcikova Z. Neuzil J, et al. Among authors: rohlena j. Cancers (Basel). 2023 Sep 8;15(18):4476. doi: 10.3390/cancers15184476. Cancers (Basel). 2023. PMID: 37760446 Free PMC article.
Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trial.
Bielcikova Z, Stursa J, Krizova L, Dong L, Spacek J, Hlousek S, Vocka M, Rohlenova K, Bartosova O, Cerny V, Padrta T, Pesta M, Michalek P, Hubackova SS, Kolostova K, Pospisilova E, Bobek V, Klezl P, Zobalova R, Endaya B, Rohlena J, Petruzelka L, Werner L, Neuzil J. Bielcikova Z, et al. Among authors: rohlena j. EClinicalMedicine. 2023 Feb 23;57:101873. doi: 10.1016/j.eclinm.2023.101873. eCollection 2023 Mar. EClinicalMedicine. 2023. PMID: 37064512 Free PMC article.
Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression.
Oh S, Jo S, Bajzikova M, Kim HS, Dao TTP, Rohlena J, Kim JM, Neuzil J, Park S. Oh S, et al. Among authors: rohlena j. Theranostics. 2023 Jan 1;13(2):438-457. doi: 10.7150/thno.75973. eCollection 2023. Theranostics. 2023. PMID: 36632231 Free PMC article.
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