Biggs BW - Search Results

1

Engineering Ca²⁺-Dependent DNA Polymerase Activity.

Biggs BW, de Paz AM, Bhan NJ, Cybulski TR, Church GM, Tyo KEJ. Biggs BW, et al. ACS Synth Biol. 2023 Nov 17;12(11):3301-3311. doi: 10.1021/acssynbio.3c00302. Epub 2023 Oct 19. ACS Synth Biol. 2023. PMID: 37856140

2

Dynamic Control of Gene Expression with Riboregulated Switchable Feedback Promoters.

Glasscock CJ, Biggs BW, Lazar JT, Arnold JH, Burdette LA, Valdes A, Kang MK, Tullman-Ercek D, Tyo KEJ, Lucks JB. Glasscock CJ, et al. Among authors: biggs bw. ACS Synth Biol. 2021 May 21;10(5):1199-1213. doi: 10.1021/acssynbio.1c00015. Epub 2021 Apr 9. ACS Synth Biol. 2021. PMID: 33834762 Free PMC article.

3

Chemically Inducible Chromosomal Evolution (CIChE) for Multicopy Metabolic Pathway Engineering.

Love AM, Biggs BW, Tyo KEJ, Ajikumar PK. Love AM, et al. Among authors: biggs bw. Methods Mol Biol. 2019;1927:37-45. doi: 10.1007/978-1-4939-9142-6_4. Methods Mol Biol. 2019. PMID: 30788784 Free PMC article.

4

Engineering Acinetobacter baylyi ADP1 for mevalonate production from lignin-derived aromatic compounds.

Arvay E, Biggs BW, Guerrero L, Jiang V, Tyo K. Arvay E, et al. Among authors: biggs bw. Metab Eng Commun. 2021 May 24;13:e00173. doi: 10.1016/j.mec.2021.e00173. eCollection 2021 Dec. Metab Eng Commun. 2021. PMID: 34430203 Free PMC article.

5

Enabling commercial success of industrial biotechnology.

Biggs BW, Alper HS, Pfleger BF, Tyo KEJ, Santos CNS, Ajikumar PK, Stephanopoulos G. Biggs BW, et al. Science. 2021 Dec 24;374(6575):1563-1565. doi: 10.1126/science.abj5040. Epub 2021 Dec 23. Science. 2021. PMID: 34941395

6

Development of a genetic toolset for the highly engineerable and metabolically versatile Acinetobacter baylyi ADP1.

Biggs BW, Bedore SR, Arvay E, Huang S, Subramanian H, McIntyre EA, Duscent-Maitland CV, Neidle EL, Tyo KEJ. Biggs BW, et al. Nucleic Acids Res. 2020 May 21;48(9):5169-5182. doi: 10.1093/nar/gkaa167. Nucleic Acids Res. 2020. PMID: 32246719 Free PMC article.

7

Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol P450 CYP725A4.

Biggs BW, Rouck JE, Kambalyal A, Arnold W, Lim CG, De Mey M, O'Neil-Johnson M, Starks CM, Das A, Ajikumar PK. Biggs BW, et al. ACS Chem Biol. 2016 May 20;11(5):1445-51. doi: 10.1021/acschembio.5b00968. Epub 2016 Mar 16. ACS Chem Biol. 2016. PMID: 26930136

8

Engineered bidirectional promoters enable rapid multi-gene co-expression optimization.

Vogl T, Kickenweiz T, Pitzer J, Sturmberger L, Weninger A, Biggs BW, Köhler EM, Baumschlager A, Fischer JE, Hyden P, Wagner M, Baumann M, Borth N, Geier M, Ajikumar PK, Glieder A. Vogl T, et al. Among authors: biggs bw. Nat Commun. 2018 Sep 4;9(1):3589. doi: 10.1038/s41467-018-05915-w. Nat Commun. 2018. PMID: 30181586 Free PMC article.

9

Multivariate modular metabolic engineering for pathway and strain optimization.

Biggs BW, De Paepe B, Santos CN, De Mey M, Kumaran Ajikumar P. Biggs BW, et al. Curr Opin Biotechnol. 2014 Oct;29:156-62. doi: 10.1016/j.copbio.2014.05.005. Epub 2014 Jun 11. Curr Opin Biotechnol. 2014. PMID: 24927371 Review.

10

Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli.

Biggs BW, Lim CG, Sagliani K, Shankar S, Stephanopoulos G, De Mey M, Ajikumar PK. Biggs BW, et al. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3209-14. doi: 10.1073/pnas.1515826113. Epub 2016 Mar 7. Proc Natl Acad Sci U S A. 2016. PMID: 26951651 Free PMC article.

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